Cognitive deficits are a core feature of schizophrenia, account for much of the impaired
functioning associated with the disorder and are not responsive to existing treatments. In this …

As a subfield of machine learning, reinforcement learning (RL) aims at optimizing decision
making by using interaction samples of an agent with its environment and the potentially …

Abstract Changes over 50 years of research on antipsychotics in schizophrenia have
occurred. A scientometric synthesis of such changes over time and a measure of …

Individuals with disorders that include psychotic symptoms (ie psychotic disorders)
experience broad cognitive impairments in the chronic state, indicating a dimension of …

Antipsychotic drugs are central to the treatment of schizophrenia and other psychotic
disorders but are ineffective for some patients and associated with side-effects and …

Background An oral compound, SEP-363856, that does not act on dopamine D2 receptors
but has agonist activity at trace amine–associated receptor 1 (TAAR1) and 5 …

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Schizophrenia is currently classified as a psychotic disorder. This article posits that this
emphasis on psychosis is a conceptual fallacy that has greatly contributed to the lack of …

Modeling of human neuropsychiatric disorders in animals is extremely challenging given the
subjective nature of many symptoms, the lack of biomarkers and objective diagnostic tests …

Despite effective pharmacological treatments for psychotic symptoms (eg, hallucinations,
delusions), functional outcomes for people with psychotic disorders are often disappointing …