Comprehensive management of cardiovascular risk factors for adults with type 2 diabetes: a scientific statement from the American Heart Association

JJ Joseph, P Deedwania, T Acharya, D Aguilar… - Circulation, 2022 - Am Heart Assoc
Cardiovascular disease remains the leading cause of death in patients with diabetes.
Cardiovascular disease in diabetes is multifactorial, and control of the cardiovascular risk …

SGLT2 inhibitors and GLP-1 receptor agonists: established and emerging indications

E Brown, HJL Heerspink, DJ Cuthbertson, JPH Wilding - The Lancet, 2021 - thelancet.com
SGLT2 inhibitors and GLP-1 receptor agonists are used in patients with type 2 diabetes as
glucose lowering therapies, with additional benefits of weight loss and blood pressure …

Sodium-glucose cotransporter protein-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists for type 2 diabetes: systematic review and network …

SC Palmer, B Tendal, RA Mustafa, PO Vandvik, S Li… - Bmj, 2021 - bmj.com
Objective To evaluate sodium-glucose cotransporter-2 (SGLT-2) inhibitors and glucagon-
like peptide-1 (GLP-1) receptor agonists in patients with type 2 diabetes at varying …

Kidney outcomes associated with use of SGLT2 inhibitors in real-world clinical practice (CVD-REAL 3): a multinational observational cohort study

HJL Heerspink, A Karasik, M Thuresson… - The lancet Diabetes & …, 2020 - thelancet.com
Background Cardiovascular and kidney outcome trials have shown that sodium-glucose co-
transporter-2 (SGLT2) inhibitors slow progression of chronic kidney disease in patients with …

SGLT2 inhibitors: a review of their antidiabetic and cardioprotective effects

A Tentolouris, P Vlachakis, E Tzeravini… - International journal of …, 2019 - mdpi.com
Type 2 diabetes mellitus is a chronic metabolic disease associated with high cardiovascular
(CV) risk. Sodium-glucose co-transporter 2 inhibitors (SGLT2i) are the latest class of …

Cardiovascular events associated with SGLT-2 inhibitors versus other glucose-lowering drugs: the CVD-REAL 2 study

M Kosiborod, CSP Lam, S Kohsaka, DJ Kim… - Journal of the American …, 2018 - jacc.org
Background Randomized trials demonstrated a lower risk of cardiovascular (CV) events with
sodium-glucose cotransporter-2 inhibitors (SGLT-2i) in patients with type 2 diabetes (T2D) at …

Sodium glucose cotransporter-2 inhibition in heart failure: potential mechanisms, clinical applications, and summary of clinical trials

Y Lytvyn, P Bjornstad, JA Udell, JA Lovshin… - Circulation, 2017 - Am Heart Assoc
Despite current established therapy, heart failure (HF) remains a leading cause of
hospitalization and mortality worldwide. Novel therapeutic targets are therefore needed to …

Association between use of sodium-glucose cotransporter 2 inhibitors, glucagon-like peptide 1 agonists, and dipeptidyl peptidase 4 inhibitors with all-cause mortality …

SL Zheng, AJ Roddick, R Aghar-Jaffar, MJ Shun-Shin… - Jama, 2018 - jamanetwork.com
Importance The comparative clinical efficacy of sodium-glucose cotransporter 2 (SGLT-2)
inhibitors, glucagon-like peptide 1 (GLP-1) agonists, and dipeptidyl peptidase 4 (DPP-4) …

Cardiovascular effects of new oral glucose-lowering agents: DPP-4 and SGLT-2 inhibitors

AJ Scheen - Circulation research, 2018 - Am Heart Assoc
Cardiovascular disease (CVD) is a major challenge in the management of type 2 diabetes
mellitus. Glucose-lowering agents that reduce the risk of major cardiovascular events would …

Heart failure and chronic kidney disease manifestation and mortality risk associations in type 2 diabetes: a large multinational cohort study

KI Birkeland, J Bodegard, JW Eriksson… - Diabetes, obesity …, 2020 - Wiley Online Library
Aims To examine the manifestation of cardiovascular or renal disease (CVRD) in patients
with type 2 diabetes (T2D) initially free from CVRD as well as the mortality risks associated …