Atherosclerosis is the underlying cause of heart attack and stroke. Early observations that
cholesterol is a key component of arterial plaques gave rise to the cholesterol hypothesis for …

Glucose and fatty acids are the major sources of energy for human body. Cholesterol, the
most abundant sterol in mammals, is a key component of cell membranes although it does …

Coat protein complex I (COPI) and COPII are required for bidirectional membrane trafficking
between the endoplasmic reticulum (ER) and the Golgi. While these core coat machineries …

Genetic and biochemical analyses of the secretory pathway have produced a detailed
picture of the molecular mechanisms involved in selective cargo transport between …

Efficient delivery of specific cargos in vivo poses a major challenge to the secretory pathway,
which shuttles products encoded by∼ 30% of the genome. Newly synthesized protein and …

Intestinal lipid transport plays a central role in fat homeostasis. Here we review the pathways
regulating intestinal absorption and delivery of dietary and biliary lipid substrates, principally …

▪ Abstract The endoplasmic reticulum (ER) and the Golgi comprise the first two steps in
protein secretion. Vesicular carriers mediate a continuous flux of proteins and lipids between …

Secretory proteins are transported to the Golgi complex in vesicles that bud from the
endoplasmic reticulum. The cytoplasmic coat protein complex II (COPII) is responsible for …

Susceptibility to the growing global public health problem of cardiovascular disease is
associated with levels of plasma lipids and lipoproteins. Several experimental strategies …

Target of rapamycin (TOR) promotes reinitiation at upstream ORF s (u ORF s) in genes that
play important roles in stem cell regulation and organogenesis in plants. Here, we report that …