The roles of Polycomb repressive complexes in mammalian development and cancer
A Piunti, A Shilatifard - Nature reviews Molecular cell biology, 2021 - nature.com
More than 80 years ago, the first Polycomb-related phenotype was identified in Drosophila
melanogaster. Later, a group of diverse genes collectively called Polycomb group (PcG) …
melanogaster. Later, a group of diverse genes collectively called Polycomb group (PcG) …
[HTML][HTML] The crucial roles of Bmi-1 in cancer: implications in pathogenesis, metastasis, drug resistance, and targeted therapies
J Xu, L Li, P Shi, H Cui, L Yang - International Journal of Molecular …, 2022 - mdpi.com
B-cell-specific Moloney murine leukemia virus integration region 1 (Bmi-1, also known as
RNF51 or PCGF4) is one of the important members of the PcG gene family, and is involved …
RNF51 or PCGF4) is one of the important members of the PcG gene family, and is involved …
[HTML][HTML] Targeting BMI-1 in B cells restores effective humoral immune responses and controls chronic viral infection
A Di Pietro, J Polmear, L Cooper, T Damelang… - Nature …, 2022 - nature.com
Ineffective antibody-mediated responses are a key characteristic of chronic viral infection.
However, our understanding of the intrinsic mechanisms that drive this dysregulation are …
However, our understanding of the intrinsic mechanisms that drive this dysregulation are …
[HTML][HTML] Senescence induced by BMI1 inhibition is a therapeutic vulnerability in H3K27M-mutant DIPG
I Balakrishnan, E Danis, A Pierce, K Madhavan… - Cell reports, 2020 - cell.com
Diffuse intrinsic pontine glioma (DIPG) is an incurable brain tumor of childhood
characterized by histone mutations at lysine 27, which results in epigenomic dysregulation …
characterized by histone mutations at lysine 27, which results in epigenomic dysregulation …
[HTML][HTML] Super-enhancers, phase-separated condensates, and 3D genome organization in cancer
SC Tang, U Vijayakumar, Y Zhang, MJ Fullwood - Cancers, 2022 - mdpi.com
Simple Summary Gene expression is primarily controlled at the level of transcription, largely
due to binding of transcription factors to specific sites on DNA, namely super-enhancers and …
due to binding of transcription factors to specific sites on DNA, namely super-enhancers and …
[HTML][HTML] Developing targeted therapies that exploit aberrant histone ubiquitination in cancer
LMP Jeusset, KJ McManus - Cells, 2019 - mdpi.com
Histone ubiquitination is a critical epigenetic mechanism regulating DNA-driven processes
such as gene transcription and DNA damage repair. Importantly, the cellular machinery …
such as gene transcription and DNA damage repair. Importantly, the cellular machinery …
[HTML][HTML] Proteogenomic analysis of enriched HGSOC tumor epithelium identifies prognostic signatures and therapeutic vulnerabilities
NW Bateman, T Abulez, AR Soltis, A McPherson… - NPJ precision …, 2024 - nature.com
We performed a deep proteogenomic analysis of bulk tumor and laser microdissection
enriched tumor cell populations from high-grade serous ovarian cancer (HGSOC) tissue …
enriched tumor cell populations from high-grade serous ovarian cancer (HGSOC) tissue …
[HTML][HTML] A novel BMI-1 inhibitor QW24 for the treatment of stem-like colorectal cancer
J Wang, Y Xing, Y Wang, Y He, L Wang, S Peng… - Journal of Experimental …, 2019 - Springer
Background Cancer-initiating cell (CIC), a functionally homogeneous stem-like cell
population, is resonsible for driving the tumor maintenance and metastasis, and is a source …
population, is resonsible for driving the tumor maintenance and metastasis, and is a source …
Roles of BMI1 in the initiation, progression, and treatment of hepatocellular carcinoma
R Wang, H Fan, M Sun, Z Lv… - Technology in Cancer …, 2022 - journals.sagepub.com
Liver cancer has high rates of morbidity and mortality, and its treatment is a global health
challenge. Hepatocellular carcinoma (HCC) accounts for 90% of all primary liver cancer …
challenge. Hepatocellular carcinoma (HCC) accounts for 90% of all primary liver cancer …
Recent progress on small molecules targeting epigenetic complexes
For many years, drug discovery studies in the field of epigenetics have focused mainly on
specific enzymes such as histone deacetylases (HDACs). However, recently there has been …
specific enzymes such as histone deacetylases (HDACs). However, recently there has been …