More than 80 years ago, the first Polycomb-related phenotype was identified in Drosophila
melanogaster. Later, a group of diverse genes collectively called Polycomb group (PcG) …

B-cell-specific Moloney murine leukemia virus integration region 1 (Bmi-1, also known as
RNF51 or PCGF4) is one of the important members of the PcG gene family, and is involved …

Ineffective antibody-mediated responses are a key characteristic of chronic viral infection.
However, our understanding of the intrinsic mechanisms that drive this dysregulation are …

Diffuse intrinsic pontine glioma (DIPG) is an incurable brain tumor of childhood
characterized by histone mutations at lysine 27, which results in epigenomic dysregulation …

Simple Summary Gene expression is primarily controlled at the level of transcription, largely
due to binding of transcription factors to specific sites on DNA, namely super-enhancers and …

Histone ubiquitination is a critical epigenetic mechanism regulating DNA-driven processes
such as gene transcription and DNA damage repair. Importantly, the cellular machinery …

We performed a deep proteogenomic analysis of bulk tumor and laser microdissection
enriched tumor cell populations from high-grade serous ovarian cancer (HGSOC) tissue …

Background Cancer-initiating cell (CIC), a functionally homogeneous stem-like cell
population, is resonsible for driving the tumor maintenance and metastasis, and is a source …

Liver cancer has high rates of morbidity and mortality, and its treatment is a global health
challenge. Hepatocellular carcinoma (HCC) accounts for 90% of all primary liver cancer …

For many years, drug discovery studies in the field of epigenetics have focused mainly on
specific enzymes such as histone deacetylases (HDACs). However, recently there has been …