It is well established that the target of rapamycin (TOR) protein kinase has pivotal roles in
controlling cell functions (including protein synthesis, cell growth and cell proliferation) and …

Oncolytic viruses are multifunctional anticancer agents with huge clinical potential, and have
recently passed the randomized Phase III clinical trial hurdle. Both wild-type and engineered …

Proliferation of Ag-specific T cells is central to the development of protective immunity. The
concomitant stimulation of the TCR and CD28 programs resting T cells to IL-2-driven clonal …

The mechanisms that regulate the TH9 subset of helper T cells and diseases mediated by
TH9 cells remain poorly defined. Here we found that the costimulatory receptor OX40 was a …

The RAS–RAF–MEK–ERK and PI3K–AKT–mTOR signaling pathways are activated through
multiple mechanisms and appear to play a major role in melanoma progression. Herein, we …

Diffuse large B‐cell lymphoma (DLBCL) is a common lymphoma entity. Although a
significant amount of DLBCL patients can be cured with modern chemotherapeutic …

A major determinant in platelet production is the megakaryocyte (MK) size that is regulated
both by ploidization and the increase in cytoplasmic volume at the end of maturation. Here …

How cAMP-dependent protein kinases [protein kinase A (PKA)] transduce the mitogenic
stimulus elicited by TSH in thyroid cells to late activation of cyclin D3-cyclin-dependent …

mTOR is an evolutionarily conserved kinase that plays a critical role in sensing and
responding to environmental determinants. Recent studies have shown that fine-tuning of …

Rapamycin, an mTOR inhibitor, has emerged as an immunosuppressive and
antiproliferative drug, and is considered a novel antitumor agent. A better understanding of …