Narcolepsy—clinical spectrum, aetiopathophysiology, diagnosis and treatment
CLA Bassetti, A Adamantidis, D Burdakov… - Nature Reviews …, 2019 - nature.com
Narcolepsy is a rare brain disorder that reflects a selective loss or dysfunction of orexin (also
known as hypocretin) neurons of the lateral hypothalamus. Narcolepsy type 1 (NT1) is …
known as hypocretin) neurons of the lateral hypothalamus. Narcolepsy type 1 (NT1) is …
Narcolepsy
TE Scammell - New England Journal of Medicine, 2015 - Mass Medical Soc
Narcolepsy | New England Journal of Medicine Skip to main content The New England Journal
of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology Clinical Medicine …
of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology Clinical Medicine …
Prefrontal cortical regulation of REM sleep
Rapid eye movement (REM) sleep is accompanied by intense cortical activity, underlying its
wake-like electroencephalogram. The neural activity inducing REM sleep is thought to …
wake-like electroencephalogram. The neural activity inducing REM sleep is thought to …
Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in mice
E Hasegawa, A Miyasaka, K Sakurai, Y Cherasse, Y Li… - Science, 2022 - science.org
The sleep cycle is characterized by alternating non–rapid eye movement (NREM) and rapid
eye movement (REM) sleeps. The mechanisms by which this cycle is generated are …
eye movement (REM) sleeps. The mechanisms by which this cycle is generated are …
The neurobiological basis of narcolepsy
CE Mahoney, A Cogswell, IJ Koralnik… - Nature Reviews …, 2019 - nature.com
Narcolepsy is the most common neurological cause of chronic sleepiness. The discovery
about 20 years ago that narcolepsy is caused by selective loss of the neurons producing …
about 20 years ago that narcolepsy is caused by selective loss of the neurons producing …
Motivational activation: a unifying hypothesis of orexin/hypocretin function
Orexins (hypocretins) are two peptides (orexin A and B) produced from the pre-pro-orexin
precursor and expressed in a limited region of dorsolateral hypothalamus. Orexins were …
precursor and expressed in a limited region of dorsolateral hypothalamus. Orexins were …
The neurobiology of sleep and wakefulness
MD Schwartz, TS Kilduff - Psychiatric Clinics, 2015 - psych.theclinics.com
Our understanding of the neural control of sleep in large part parallels the history of
neuroscience. As new tools and methodologies have become available to the research …
neuroscience. As new tools and methodologies have become available to the research …
Safety and efficacy of pitolisant on cataplexy in patients with narcolepsy: a randomised, double-blind, placebo-controlled trial
Z Szakacs, Y Dauvilliers, V Mikhaylov… - The Lancet …, 2017 - thelancet.com
Background Histaminergic neurons are crucial to maintain wakefulness, but their role in
cataplexy is unknown. We assessed the safety and efficacy of pitolisant, a histamine H3 …
cataplexy is unknown. We assessed the safety and efficacy of pitolisant, a histamine H3 …
Hypocretin (orexin) biology and the pathophysiology of narcolepsy with cataplexy
The discovery of hypocretins (orexins) and their causal implication in narcolepsy is the most
important advance in sleep research and sleep medicine since the discovery of rapid eye …
important advance in sleep research and sleep medicine since the discovery of rapid eye …
A hypothalamic circuit for the circadian control of aggression
WD Todd, H Fenselau, JL Wang, R Zhang… - Nature …, 2018 - nature.com
Abstract 'Sundowning'in dementia and Alzheimer's disease is characterized by early-
evening agitation and aggression. While such periodicity suggests a circadian origin …
evening agitation and aggression. While such periodicity suggests a circadian origin …