The dynamics of the skin's immune system

AV Nguyen, AM Soulika - International journal of molecular sciences, 2019 - mdpi.com
The skin is a complex organ that has devised numerous strategies, such as physical,
chemical, and microbiological barriers, to protect the host from external insults. In addition …

Neutrophil diversity in health and disease

C Silvestre-Roig, ZG Fridlender, M Glogauer… - Trends in …, 2019 - cell.com
New evidence has challenged the outdated dogma that neutrophils are a homogeneous
population of short-lived cells. Although neutrophil subpopulations with distinct functions …

Neutrophils at the crossroads of innate and adaptive immunity

C Rosales - Journal of Leucocyte Biology, 2020 - academic.oup.com
Neutrophils are the most abundant leukocytes in blood. From the circulation, they are quickly
mobilized to sites of inflammation and/or infection. At the affected tissues, neutrophils display …

The Mechanisms of Disease Caused by Acinetobacter baumannii

FC Morris, C Dexter, X Kostoulias, MI Uddin… - Frontiers in …, 2019 - frontiersin.org
Acinetobacter baumannii is a Gram negative opportunistic pathogen that has demonstrated
a significant insurgence in the prevalence of infections over recent decades. With only a …

Neutrophils: between host defence, immune modulation, and tissue injury

P Kruger, M Saffarzadeh, ANR Weber, N Rieber… - PLoS …, 2015 - journals.plos.org
Neutrophils, the most abundant human immune cells, are rapidly recruited to sites of
infection, where they fulfill their life-saving antimicrobial functions. While traditionally …

Neutrophils at work

WM Nauseef, N Borregaard - Nature immunology, 2014 - nature.com
In this Review we discuss data demonstrating recently recognized aspects of neutrophil
homeostasis in the steady state, granulopoiesis in'emergency'conditions and interactions of …

Origin and role of a subset of tumor-associated neutrophils with antigen-presenting cell features in early-stage human lung cancer

S Singhal, PS Bhojnagarwala, S O'Brien, EK Moon… - Cancer cell, 2016 - cell.com
Based on studies in mouse tumor models, granulocytes appear to play a tumor-promoting
role. However, there are limited data about the phenotype and function of tumor-associated …

Tumor associated macrophages and neutrophils in cancer

MR Galdiero, E Bonavita, I Barajon, C Garlanda… - Immunobiology, 2013 - Elsevier
The tumor microenvironment is a complex framework, in which myeloid cells play important
roles in sculpting cancer development from tumor initiation to metastasis. Immune cells are …

N2‐Polarized Neutrophils Guide Bone Mesenchymal Stem Cell Recruitment and Initiate Bone Regeneration: A Missing Piece of the Bone Regeneration Puzzle

B Cai, D Lin, Y Li, L Wang, J Xie, T Dai, F Liu… - Advanced …, 2021 - Wiley Online Library
The role of neutrophils in bone regeneration remains elusive. In this study, it is shown that
intramuscular implantation of interleukin‐8 (IL‐8)(commonly recognized as a chemotactic …

Neutrophils in the tumor microenvironment: trying to heal the wound that cannot heal

KL Singel, BH Segal - Immunological reviews, 2016 - Wiley Online Library
Neutrophils are the first responders to infection and injury and are critical for antimicrobial
host defense. Through the generation of reactive oxidants, activation of granular constituents …