Gastric cancer (GC) is one of the most prevalent malignant types in the world and an
aggressive disease with a poor 5-year survival. This cancer is biologically and genetically …

For many years, transcription factor Sp1 was viewed as a basal transcription factor and
relegated to a role in the regulation of so‐called housekeeping genes. Identification of Sp1's …

Oesophageal cancers are prominent worldwide; however, there are few targeted therapies
and survival rates for these cancers remain dismal. Here we performed a comprehensive …

Familial gastric cancer comprises at least three major syndromes: hereditary diffuse gastric
cancer, gastric adenocarcinoma and proximal polyposis of the stomach, and familial …

Gastroesophageal adenocarcinoma (GEA) and squamous esophageal cancer (ESCC) are
responsible for> 1 million deaths annually globally. Until now, patients with metastatic GEA …

Helicobacter pylori (H. pylori) is one of the most common human pathogens, affecting half of
the world's population. Approximately 20% of the infected patients develop gastric ulcers or …

Pancreatic cancer is one of the common malignant tumors of the digestive system and is
known as the “king of cancers”. It is extremely difficult to diagnose at an early stage, the …

Introduction Germline mutation in CDH1 (E-cadherin) tumor suppressor gene is associated
with hereditary diffuse gastric cancer (HDGC) and lobular breast cancers (LBC). E-Cadherin …

E-cadherin is the major adhesion receptor in epithelial adherens junctions, which connect
cells to form tissues and are essential for morphogenesis and homeostasis. The mechanism …

Gastric cancer is the fourth most common malignancy and the second leading cause of
cancer-related death worldwide. 1 Although the incidence of gastric cancer in North America …