Histone demethylases play a critical role in gene transcription regulation and have been
implicated in cancer. Numerous reports have highlighted the overexpression of histone …

Sequence-based genetic testing identifies causative variants in~ 50% of individuals with
developmental and epileptic encephalopathies (DEEs). Aberrant changes in DNA …

Abstract DNA methylation classifiers (“episignatures”) help to determine the pathogenicity of
variants of uncertain significance (VUS). However, their sensitivity is limited due to their …

Gestational diabetes mellitus (GDM) represents a prevalent complication during pregnancy,
exerting both short-term and long-term impacts on maternal and offspring health. This review …

Sex differences in the epidemiology and clinical characteristics of schizophrenia are well-
known; however, the molecular mechanisms underlying these differences remain unclear …

Exposure to bisphenol S (BPS) is known to adversely affect neuronal development. As
pivotal components of neuronal polarization, axons and dendrites are indispensable …

The establishment and maintenance of heterochromatin, a specific chromatin structure
essential for genomic stability and regulation, rely on intricate interactions between …

The hippocampus plays major roles in learning and memory, and its formation requires
precise coordination of patterning, cell proliferation, differentiation, and migration. Here we …

Background Mendelian disorders of the epigenetic machinery (MDEMs) are a newly
identified group of neurodevelopmental disorders (NDDs) and multiple congenital …

Background: A subset of developmental disorders (DD) is characterized by disease-specific
genome-wide methylation changes. These episignatures inform about underlying …