Exploring the potential of histone demethylase inhibition in multi-therapeutic approaches for cancer treatment
D Li, H Liang, Y Wei, H Xiao, X Peng, W Pan - European Journal of …, 2023 - Elsevier
Histone demethylases play a critical role in gene transcription regulation and have been
implicated in cancer. Numerous reports have highlighted the overexpression of histone …
implicated in cancer. Numerous reports have highlighted the overexpression of histone …
Diagnostic utility of DNA methylation analysis in genetically unsolved pediatric epilepsies and CHD2 episignature refinement
CW LaFlamme, C Rastin, S Sengupta… - Nature …, 2024 - nature.com
Sequence-based genetic testing identifies causative variants in~ 50% of individuals with
developmental and epileptic encephalopathies (DEEs). Aberrant changes in DNA …
developmental and epileptic encephalopathies (DEEs). Aberrant changes in DNA …
Episignature analysis of moderate effects and mosaics
K Oexle, M Zech, LG Stühn, S Siegert… - European Journal of …, 2023 - nature.com
Abstract DNA methylation classifiers (“episignatures”) help to determine the pathogenicity of
variants of uncertain significance (VUS). However, their sensitivity is limited due to their …
variants of uncertain significance (VUS). However, their sensitivity is limited due to their …
[HTML][HTML] Deciphering DNA Methylation in Gestational Diabetes Mellitus: Epigenetic Regulation and Potential Clinical Applications
N Li, HY Liu, SM Liu - International Journal of Molecular Sciences, 2024 - mdpi.com
Gestational diabetes mellitus (GDM) represents a prevalent complication during pregnancy,
exerting both short-term and long-term impacts on maternal and offspring health. This review …
exerting both short-term and long-term impacts on maternal and offspring health. This review …
Sex effects on DNA methylation affect discovery in epigenome-wide association study of schizophrenia
M Tesfaye, LM Spindola, AK Stavrum, A Shadrin… - Molecular …, 2024 - nature.com
Sex differences in the epidemiology and clinical characteristics of schizophrenia are well-
known; however, the molecular mechanisms underlying these differences remain unclear …
known; however, the molecular mechanisms underlying these differences remain unclear …
[HTML][HTML] Bisphenol S impairs mitochondrial function by targeting Myo19/oxidative phosphorylation pathway contributing to axonal and dendritic injury
X Zhang, H Gong, Y Zhao, Y Wu, J Cheng… - Environment …, 2024 - Elsevier
Exposure to bisphenol S (BPS) is known to adversely affect neuronal development. As
pivotal components of neuronal polarization, axons and dendrites are indispensable …
pivotal components of neuronal polarization, axons and dendrites are indispensable …
Structural insights into the binding mechanism of Clr4 methyltransferase to H3K9 methylated nucleosome
C Saab, J Stephan, E Akoury - Scientific Reports, 2024 - nature.com
The establishment and maintenance of heterochromatin, a specific chromatin structure
essential for genomic stability and regulation, rely on intricate interactions between …
essential for genomic stability and regulation, rely on intricate interactions between …
KDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors
B Zhang, C Zhao, W Shen, W Li, Y Zheng… - Nature …, 2023 - nature.com
The hippocampus plays major roles in learning and memory, and its formation requires
precise coordination of patterning, cell proliferation, differentiation, and migration. Here we …
precise coordination of patterning, cell proliferation, differentiation, and migration. Here we …
Identification of novel Mendelian disorders of the epigenetic machinery (MDEMs)-associated functional mutations and neurodevelopmental disorders
S Li, H Li, D Liu, Q Xing, X Chen… - … Journal of Medicine, 2023 - academic.oup.com
Background Mendelian disorders of the epigenetic machinery (MDEMs) are a newly
identified group of neurodevelopmental disorders (NDDs) and multiple congenital …
identified group of neurodevelopmental disorders (NDDs) and multiple congenital …
Nanopore sequencing-based episignature detection
M Geysens, B Huremagic, E Souche, J Breckpot… - medRxiv, 2024 - medrxiv.org
Background: A subset of developmental disorders (DD) is characterized by disease-specific
genome-wide methylation changes. These episignatures inform about underlying …
genome-wide methylation changes. These episignatures inform about underlying …