Maintaining optimal mitochondrial function is a feature of health. Mitophagy removes and
recycles damaged mitochondria and regulates the biogenesis of new, fully functional ones …

Tau protein is involved in various cellular processes, including having a canonical role in
binding and stabilization of microtubules in neurons. Tauopathies are neurodegenerative …

Mitochondria play key roles in bioenergetics, metabolism, and signaling; therefore, stable
mitochondrial function is essential for cell survival, particularly in energy-intensive neuronal …

Mitophagy is a selective autophagic process, essential for cellular homeostasis, that
eliminates dysfunctional mitochondria. Activated by inner membrane depolarization, it plays …

Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly
globally. Emerging evidence has demonstrated microglia-driven neuroinflammation as a key …

Alzheimer's disease (AD) is the most common cause of dementia and is currently one of the
biggest public health concerns in the world. Mitochondrial dysfunction in neurons is one of …

The entorhinal-hippocampal system contains distinct networks subserving declarative
memory. This system is selectively vulnerable to changes of ageing and pathological …

Mitochondria and mitochondria‐mediated signalling pathways are known to control synaptic
signalling, as well as long‐lasting changes in neuronal structure and function. Mitochondrial …

Mitophagy has a pivotal protective function in the pathogenesis of neurological disorders.
However, the mechanism of its modulation remains elusive, especially in PINK1-mediated …

The ubiquitin kinase-ligase pair PINK1-PRKN recognizes and transiently labels damaged
mitochondria with ubiquitin phosphorylated at Ser65 (p-S65-Ub) to mediate their selective …