Neutrophils are emerging as an important player in skeletal muscle injury and repair.
Neutrophils accumulate in injured tissue, thus releasing inflammatory factors, proteases and …

Immune cells undergo rapid and extensive metabolic changes during inflammation. In
addition to contributing to energetic and biosynthetic demands, metabolites can also …

Cardiovascular diseases (CVDs) are the leading cause of death globally, resulting in a
major health burden. Thus, an urgent need exists for exploring effective therapeutic targets …

Mycoplasma pneumoniae is a common cause of community-acquired pneumonia in which
neutrophils play a critical role. Immune-responsive gene 1 (IRG1), responsible for itaconate …

Itaconate was initially identified as an antimicrobial compound produced by myeloid cells.
Beyond its antimicrobial role, itaconate may also serve as a crucial metabolic and immune …

Immune cell activation triggers signaling cascades leading to transcriptional reprogramming,
but also strongly impacts on the cell's metabolic activity to provide energy and biomolecules …

Heterotopic ossification (HO) is a challenging condition that occurs after musculoskeletal
injury and is characterized by the formation of bone in non-skeletal tissues. While the effect …

The mammalian immune system is constantly surveying our tissues to clear pathogens and
maintain tissue homeostasis. In order to fulfill these tasks, immune cells take up nutrients to …

The ability of mitochondria to transform the energy we obtain from food into cell
phosphorylation potential has long been appreciated. However, recent decades have seen …

Acute lung injury (ALI) is defined as the acute onset of diffuse bilateral pulmonary infiltration,
leading to PaO 2/FiO 2≤ 300 mmHg without clinical evidence of left atrial hypertension …