Stimulus-cleavable chemistry in the field of controlled drug delivery

Y Xue, H Bai, B Peng, B Fang, J Baell, L Li… - Chemical Society …, 2021 - pubs.rsc.org
Stimulus-cleavable nanoscale drug delivery systems are receiving significant attention
owing to their capability of achieving exquisite control over drug release via the exposure to …

Redox-responsive drug delivery systems: a chemical perspective

HF Abed, WH Abuwatfa, GA Husseini - Nanomaterials, 2022 - mdpi.com
With the widespread global impact of cancer on humans and the extensive side effects
associated with current cancer treatments, a novel, effective, and safe treatment is needed …

Stimuli-responsive destructible polymeric hydrogels based on irreversible covalent bond dissociation

S Shahi, H Roghani-Mamaqani, S Talebi… - Polymer …, 2022 - pubs.rsc.org
Covalently crosslinked stimuli-destructible hydrogels with the ability of irreversible stimuli-
controlled bond dissociation have attracted great attention due to their easy preparation …

Quantitative, Regiospecific, and Stereoselective Radical Ring-Opening Polymerization of Monosaccharide Cyclic Ketene Acetals

NC Jiang, Z Zhou, J Niu - Journal of the American Chemical …, 2024 - ACS Publications
Cyclic ketene acetals (CKAs) are among the most well-studied monomers for radical ring-
opening polymerization (rROP). However, ring-retaining side reactions and low reactivities …

Multi-stimuli-responsive, liposome-crosslinked poly (ethylene glycol) hydrogels for drug delivery

LL Palmese, M Fan, RA Scott, H Tan… - Journal of Biomaterials …, 2020 - Taylor & Francis
The development of hybrid hydrogels has been of great interest over recent decades,
especially in the field of biomaterials. Such hydrogels provide various opportunities in tissue …

Agitation-induced aggregation of lysine-and interchain cysteine-linked antibody-drug conjugates

F Johann, S Wöll, M Winzer, H Gieseler - Journal of Pharmaceutical …, 2024 - Elsevier
Drug conjugation to an antibody can affect its stability, which depends on factors such as the
conjugation technique used, drug-linker properties, and stress encountered. This study …

Site-specific radioiodination of an anti-HER2 single domain antibody fragment with a residualizing prosthetic agent

Y Feng, Z Zhou, D McDougald, RL Meshaw… - Nuclear medicine and …, 2021 - Elsevier
Introduction As a consequence of their small size, high stability and high affinity, single
domain antibody fragments (sdAbs) are appealing targeting vectors for radiopharmaceutical …

Therapeutic Oligonucleotides: An Outlook on Chemical Strategies to Improve Endosomal Trafficking

P Mangla, Q Vicentini, A Biscans - Cells, 2023 - mdpi.com
The potential of oligonucleotide therapeutics is undeniable as more than 15 drugs have
been approved to treat various diseases in the liver, central nervous system (CNS), and …

Stable Immobilization of DNA to Silica Surfaces by Sequential Michael Addition Reactions Developed with Insights from Confocal Raman Microscopy

GJ Myres, JM Harris - Analytical Chemistry, 2023 - ACS Publications
The immobilization of DNA to surfaces is required for numerous biosensing applications
related to the capture of target DNA sequences, proteins, or small-molecule analytes from …

Nanomedicines Based on Responsive Nanocarriers for Cancer Therapy

ZS Liu, J Wen, CY Huang, PW Zhang… - Advanced …, 2024 - Wiley Online Library
Nanotechnology has been widely used in drug design in recent years, showing great
potential and advantages in tumor therapy. However, the application of most traditional …