Stimulus-cleavable chemistry in the field of controlled drug delivery
Stimulus-cleavable nanoscale drug delivery systems are receiving significant attention
owing to their capability of achieving exquisite control over drug release via the exposure to …
owing to their capability of achieving exquisite control over drug release via the exposure to …
Redox-responsive drug delivery systems: a chemical perspective
HF Abed, WH Abuwatfa, GA Husseini - Nanomaterials, 2022 - mdpi.com
With the widespread global impact of cancer on humans and the extensive side effects
associated with current cancer treatments, a novel, effective, and safe treatment is needed …
associated with current cancer treatments, a novel, effective, and safe treatment is needed …
Stimuli-responsive destructible polymeric hydrogels based on irreversible covalent bond dissociation
Covalently crosslinked stimuli-destructible hydrogels with the ability of irreversible stimuli-
controlled bond dissociation have attracted great attention due to their easy preparation …
controlled bond dissociation have attracted great attention due to their easy preparation …
Quantitative, Regiospecific, and Stereoselective Radical Ring-Opening Polymerization of Monosaccharide Cyclic Ketene Acetals
Cyclic ketene acetals (CKAs) are among the most well-studied monomers for radical ring-
opening polymerization (rROP). However, ring-retaining side reactions and low reactivities …
opening polymerization (rROP). However, ring-retaining side reactions and low reactivities …
Multi-stimuli-responsive, liposome-crosslinked poly (ethylene glycol) hydrogels for drug delivery
The development of hybrid hydrogels has been of great interest over recent decades,
especially in the field of biomaterials. Such hydrogels provide various opportunities in tissue …
especially in the field of biomaterials. Such hydrogels provide various opportunities in tissue …
Agitation-induced aggregation of lysine-and interchain cysteine-linked antibody-drug conjugates
F Johann, S Wöll, M Winzer, H Gieseler - Journal of Pharmaceutical …, 2024 - Elsevier
Drug conjugation to an antibody can affect its stability, which depends on factors such as the
conjugation technique used, drug-linker properties, and stress encountered. This study …
conjugation technique used, drug-linker properties, and stress encountered. This study …
Site-specific radioiodination of an anti-HER2 single domain antibody fragment with a residualizing prosthetic agent
Y Feng, Z Zhou, D McDougald, RL Meshaw… - Nuclear medicine and …, 2021 - Elsevier
Introduction As a consequence of their small size, high stability and high affinity, single
domain antibody fragments (sdAbs) are appealing targeting vectors for radiopharmaceutical …
domain antibody fragments (sdAbs) are appealing targeting vectors for radiopharmaceutical …
Therapeutic Oligonucleotides: An Outlook on Chemical Strategies to Improve Endosomal Trafficking
P Mangla, Q Vicentini, A Biscans - Cells, 2023 - mdpi.com
The potential of oligonucleotide therapeutics is undeniable as more than 15 drugs have
been approved to treat various diseases in the liver, central nervous system (CNS), and …
been approved to treat various diseases in the liver, central nervous system (CNS), and …
Stable Immobilization of DNA to Silica Surfaces by Sequential Michael Addition Reactions Developed with Insights from Confocal Raman Microscopy
GJ Myres, JM Harris - Analytical Chemistry, 2023 - ACS Publications
The immobilization of DNA to surfaces is required for numerous biosensing applications
related to the capture of target DNA sequences, proteins, or small-molecule analytes from …
related to the capture of target DNA sequences, proteins, or small-molecule analytes from …
Nanomedicines Based on Responsive Nanocarriers for Cancer Therapy
ZS Liu, J Wen, CY Huang, PW Zhang… - Advanced …, 2024 - Wiley Online Library
Nanotechnology has been widely used in drug design in recent years, showing great
potential and advantages in tumor therapy. However, the application of most traditional …
potential and advantages in tumor therapy. However, the application of most traditional …