Approaching genetics through the MHC lens: tools and methods for HLA research
V Douillard, EC Castelli, SJ Mack, JA Hollenbach… - Frontiers in …, 2021 - frontiersin.org
The current SARS-CoV-2 pandemic era launched an immediate and broad response of the
research community with studies both about the virus and host genetics. Research in …
research community with studies both about the virus and host genetics. Research in …
Current HLA testing recommendations to support HCT
Supporting allogeneic hematopoietic cell transplantation (HCT) is an integral function of the
clinical HLA laboratory, which provides HLA testing for recipients and donors. However, the …
clinical HLA laboratory, which provides HLA testing for recipients and donors. However, the …
Stem cell donor registry activities during the COVID-19 pandemic: a field report by DKMS
T Mengling, G Rall, SN Bernas, N Astreou… - Bone Marrow …, 2021 - nature.com
The COVID-19 pandemic has serious implications also for patients with other diseases.
Here, we describe the effects of the pandemic on unrelated hematopoietic stem cell …
Here, we describe the effects of the pandemic on unrelated hematopoietic stem cell …
Post‐COVID‐19 condition in the German working population: A cross‐sectional study of 200,000 registered stem cell donors
Abstract Background The SARS‐CoV‐2 pandemic has strained health systems worldwide,
and infection numbers continue to rise. While previous data have already shown that many …
and infection numbers continue to rise. While previous data have already shown that many …
Individual HLA-A, -B, -C, and -DRB1 Genotypes Are No Major Factors Which Determine COVID-19 Severity
J Schetelig, F Heidenreich, H Baldauf, S Trost… - Frontiers in …, 2021 - frontiersin.org
HLA molecules are key restrictive elements to present intracellular antigens at the
crossroads of an effective T-cell response against SARS-CoV-2. To determine the impact of …
crossroads of an effective T-cell response against SARS-CoV-2. To determine the impact of …
Small volume bone marrow aspirates with high progenitor cell concentrations maximize cell therapy dose manufacture and substantially reduce donor hemoglobin …
J Epah, G Spohn, K Preiß, MM Müller, J Dörr, R Bauer… - BMC medicine, 2023 - Springer
Background Bone marrow (BM) transplantation is a life-saving therapy for hematological
diseases, and the BM harbors also highly useful (progenitor) cell types for novel cell …
diseases, and the BM harbors also highly useful (progenitor) cell types for novel cell …
Haplotype motif-based models for KIR-genotype informed selection of hematopoietic cell donors fail to predict outcome of patients with myelodysplastic syndromes or …
J Schetelig, H Baldauf, L Koster, M Kuxhausen… - Frontiers in …, 2021 - frontiersin.org
Results from registry studies suggest that harnessing Natural Killer (NK) cell reactivity
mediated through Killer cell Immunoglobulin-like Receptors (KIR) could reduce the risk of …
mediated through Killer cell Immunoglobulin-like Receptors (KIR) could reduce the risk of …
5 years DKMS Chile: approach, results and impact of the first unrelated stem cell donor center in Chile
F Barriga, UV Solloch, A Giani, J Palma… - Frontiers in …, 2023 - frontiersin.org
Introduction Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is performed
worldwide to treat blood cancer and other life-threatening blood disorders. As successful …
worldwide to treat blood cancer and other life-threatening blood disorders. As successful …
[HTML][HTML] HLA-E typing of more than 2.5 million potential hematopoietic stem cell donors: methods and population-specific allele frequencies
J Sauter, K Putke, D Schefzyk, J Pruschke… - Human Immunology, 2021 - Elsevier
We developed a cost-efficient workflow for genotyping HLA-E by NGS and applied it for
genotyping more than 2.5 million potential stem cell donors. The data obtained were used to …
genotyping more than 2.5 million potential stem cell donors. The data obtained were used to …
Immunogenetics in stem cell donor registry work: The DKMS example (Part 2)
AH Schmidt, J Sauter, DM Baier, J Daiss… - International journal …, 2020 - Wiley Online Library
DKMS is a leading stem cell donor registry with more than 9 million donors. Donor registry
activities share many touch points with topics from immunogenetics or population genetics …
activities share many touch points with topics from immunogenetics or population genetics …