Recent human and animal model experimental studies revealed novel pathways for fluid
movement, immune cell trafficking and metabolic waste clearance in CNS. These studies …

The blood-brain barrier (BBB) is a protective semi-permeable structure that regulates the
exchange of biomolecules between the peripheral blood and the central nervous system …

Distinguishing pathological gait is challenging in neurology because of the difficulty of
capturing total body movement and its analysis. We aimed to obtain a convenient recording …

Abstract Background Cathepsin S (CTSS) is a cysteine protease that played diverse roles in
immunity, tumor metastasis, aging and other pathological alterations. At the cellular level …

Midlife metabolic syndrome (MetS) is associated with cognitive impairment in late life. The
mechanism of delayed MetS-related cognitive dysfunction (MetSCD) is not clear, but it has …

Pathophysiological mechanisms contributing to obesity-related VCID include adipose tissue
inflammation, altered adipokine secretion, insulin resistance, and alterations of the gut-brain …

Hydrocephalus can affect brain function and motor ability. Current treatments mostly involve
invasive surgeries, with a high risk of postoperative infections and failure. A successful …

Cytochrome P450 metabolism of arachidonic acid produces epoxyeicosatrienoates (EETs)
and hydroxyeicosatetraenoates (HETEs). Both classes of eicosanoids play important and …