[HTML][HTML] Functionalized niosomes as a smart delivery device in cancer and fungal infection

P Aparajay, A Dev - European journal of pharmaceutical sciences, 2022 - Elsevier
Various diseases remain untreated due to lack of suitable therapeutic moiety or a suitable
drug delivery device, especially where toxicities and side effects are the primary reason for …

Understanding the versatile roles and applications of EpCAM in cancers: from bench to bedside

Y Liu, Y Wang, S Sun, Z Chen, S Xiang, Z Ding… - … hematology & oncology, 2022 - Springer
Epithelial cell adhesion molecule (EpCAM) functions not only in physiological processes but
also participates in the development and progression of cancer. In recent decades …

Photothermal therapy with HER2-targeted silver nanoparticles leading to cancer remission

VO Shipunova, MM Belova, PA Kotelnikova… - Pharmaceutics, 2022 - mdpi.com
Nanoparticles exhibiting the localized surface plasmon resonance (LSPR) phenomenon are
promising tools for diagnostics and cancer treatment. Among widely used metal …

Targeted nuclear medicine. Seek and destroy

VM Tolmachev, VI Chernov… - Russian Chemical …, 2022 - iopscience.iop.org
The targeted delivery of radionuclides to tumours holds great promise for diagnosis and
treatment of malignant neoplasms. The development of scaffold proteins has significantly …

PLGA Nanoparticles decorated with anti-HER2 affibody for targeted delivery and photoinduced cell death

VO Shipunova, AS Sogomonyan, IV Zelepukin… - Molecules, 2021 - mdpi.com
The effect of enhanced permeability and retention is often not sufficient for highly effective
cancer therapy with nanoparticles, and the development of active targeted drug delivery …

Advanced situation with recombinant toxins: Diversity, production and application purposes

E Efremenko, A Aslanli, I Lyagin - International Journal of Molecular …, 2023 - mdpi.com
Today, the production and use of various samples of recombinant protein/polypeptide toxins
is known and is actively developing. This review presents state-of-the-art in research and …

Comparative evaluation of engineered polypeptide scaffolds in HER2-targeting magnetic nanocarrier delivery

VO Shipunova, OA Kolesnikova, PA Kotelnikova… - ACS …, 2021 - ACS Publications
Targeted drug delivery is one of the most intriguing and challenging issues in modern
biomedicine. For active targeting, full-size IgG molecules (150 kDa) are usually used …

[HTML][HTML] Artificial scaffold polypeptides as an efficient tool for the targeted delivery of nanostructures in vitro and in vivo

VO Shipunova, SM Deyev - Acta naturae, 2022 - ncbi.nlm.nih.gov
The use of traditional tools for the targeted delivery of nanostructures, such as antibodies,
transferrin, lectins, or aptamers, often leads to an entire range of undesirable effects. The …

Genetically encoded self-assembling protein nanoparticles for the targeted delivery in vitro and in vivo

AS Obozina, EN Komedchikova, OA Kolesnikova… - Pharmaceutics, 2023 - mdpi.com
Targeted nanoparticles of different origins are considered as new-generation diagnostic and
therapeutic tools. However, there are no targeted drug formulations within the composition of …

Strategies to mitigate the on-and off-target toxicities of recombinant immunotoxins: an antibody engineering perspective

M Li, S Mei, Y Yang, Y Shen, L Chen - Antibody therapeutics, 2022 - academic.oup.com
Targeted cancer therapies using immunotoxins have achieved remarkable efficacy in
hematological malignancies. However, the clinical development of immunotoxins is also …