Particle design via spherical agglomeration: A critical review of controlling parameters, rate processes and modelling
Particle design via spherical agglomeration is a size enlargement technique used in various
bulk and fine chemical industries, with recent interest extending into pharmaceuticals, in …
bulk and fine chemical industries, with recent interest extending into pharmaceuticals, in …
Current trends in API co-processing: spherical crystallization and co-precipitation techniques
Abstract Active Pharmaceutical Ingredients (APIs) do not always exhibit processable
physical properties, which makes their processing in an industrial setup very demanding …
physical properties, which makes their processing in an industrial setup very demanding …
Crystal population balance formulation and solution methods: a review
Crystallization is an important part of many chemical industries. Efforts are being invested to
improve the performance of the crystallization process by designing novel crystallizers. An …
improve the performance of the crystallization process by designing novel crystallizers. An …
[HTML][HTML] Advances in reactive co-precipitation technology for preparing high-performance cathodes
Reactive crystallization plays an essential role in the synthesis of high-quality precursors
with a narrow particle size distribution, dense packing, and high sphericity. These features …
with a narrow particle size distribution, dense packing, and high sphericity. These features …
Design of the spherical agglomerate size in crystallization by developing a two‐step bridging mechanism and the model
Spherical agglomeration technology can produce high‐performance spherical particles in a
single crystallization unit, although it is still challenging to control the particle size and …
single crystallization unit, although it is still challenging to control the particle size and …
Integrated Continuous Crystallization–-Spherical Agglomeration (CCSA) Process for the Intensified Manufacturing of Atorvastatin Calcium
This study applies an innovative two-stage continuous manufacturing process for
atorvastatin calcium (ASC), focusing on the integration of process intensification through …
atorvastatin calcium (ASC), focusing on the integration of process intensification through …
Strategy of selecting solvent systems for spherical agglomeration by the Lifshitz-van der Waals acid-base approach
A strategy for rationally selecting solvent systems of spherical agglomeration is proposed for
the first time. It emphasizes that followed by crystallization and phase separation, spherical …
the first time. It emphasizes that followed by crystallization and phase separation, spherical …
Tuning the particle sizes in spherical agglomeration
This paper presents an experimental technique for tuning the size of spherical agglomerates
together with a simple model that provides qualitative information on the agglomerate size …
together with a simple model that provides qualitative information on the agglomerate size …
Application of TUSSIM with a variable Tromp curve for predicting optimal operation of multi-compartment mills with various ball size distributions
A true unsteady-state simulator (TUSSIM) for ball milling was integrated with a variable
Tromp curve for classification to simulate and optimize closed-circuit, multi-compartment …
Tromp curve for classification to simulate and optimize closed-circuit, multi-compartment …
A comparative study of continuous operation between a dynamic baffle crystallizer and a stirred tank crystallizer
YC Liu, D Dunn, M Lipari, A Barton, P Firth… - Chemical Engineering …, 2019 - Elsevier
Crystallization, often as the final isolation and purification step in drug substance
manufacturing, has substantial impact on downstream efficiency and final drug product …
manufacturing, has substantial impact on downstream efficiency and final drug product …