The hypothalamus is among the most phylogenetically conserved regions in the vertebrate
brain, reflecting its critical role in maintaining physiological and behavioural homeostasis. By …

One decade ago, our laboratory provided the first direct evidence linking orexin/hypocretin
signaling with drug seeking by showing that activation of these neurons promotes …

The lateral hypothalamus (LH) is a functionally and anatomically complex brain region that
is involved in the regulation of many behavioral and physiological processes including …

In the brain, long-term memories correspond to changes in synaptic weights after certain
patterns of neural activity. Behaviourally, this corresponds to a change in action evoked by a …

Converging evidence for an essential function of the lateral hypothalamus (LHA) in the
control of feeding behavior has been accumulating since the classic work conducted almost …

Appropriate motor control is critical for normal life, and requires hypothalamic
hypocretin/orexin neurons (HONs). HONs are slowly regulated by nutrients, but also display …

The lateral hypothalamic area (LHA) lies at the intersection of multiple neural and humoral
systems and orchestrates fundamental aspects of behavior. Two neuronal cell types found in …

An array of neuromodulators, including monoamines and neuropeptides, regulate most
behavioural and physiological traits. In the past decade, dramatic progress has been made …

Hypothalamic neurons that produce the peptide transmitters orexins/hypocretins (HONs)
broadcast their predominantly neuroexcitatory outputs to the entire brain via their extremely …

Reducing sleep hours is a risk factor for developing cardiovascular, metabolic, and
psychiatric disorders. Furthermore, previous studies have shown that reduction in sleep time …