Abstract Treatment-resistant depression affects up to 20% of individuals suffering from major
depressive disorder (MDD). The medications currently available to treat depression …

Inflammatory cytokines can sometimes trigger depression in humans, are often associated
with depression, and can elicit some behaviors in animals that are homologous to major …

Substantial evidence indicates an association between clinical depression and altered
immune function. Systemic administration of bacterial lipopolysaccharide (LPS) is commonly …

Maternal immune activation (MIA) puts offspring at greater risk for neurodevelopmental
disorders associated with impaired social behavior. While it is known that immune signaling …

Neuroinflammation is a condition characterized by the elaboration of proinflammatory
mediators within the central nervous system. Neuroinflammation has emerged as a …

Neuroinflammation is the central nervous system's response to: injury, infection, and
abnormal neural activity. Inflammatory processes are known to mediate many diseases, and …

Background Early-life adversity (ELA) has been linked to higher depression risk across the
life span and chronic inflammatory conditions that contribute to earlier mortality. In this study …

ABSTRACT Introduction: Tryptophan hydroxylase 2 (TPH2) is the key, rate-limiting enzyme
of serotonin (5-HT) synthesis in the brain. Some polymorphic variants of the human Tph2 …

There are significant differences in the immune response and in the susceptibility to
autoimmune diseases among rodent strains. It would thus be expected that the contribution …

Sepsis is a systemic inflammatory response to infection, with no preventative strategies. In
this study, we identify a role for habitual physical activity in the prevention of adipose tissue …