TRPC channels: Structure, function, regulation and recent advances in small molecular probes
Transient receptor potential canonical (TRPC) channels constitute a group of receptor-
operated calcium-permeable nonselective cation channels of the TRP superfamily. The …
operated calcium-permeable nonselective cation channels of the TRP superfamily. The …
Phosphoinositides: tiny lipids with giant impact on cell regulation
T Balla - Physiological reviews, 2013 - journals.physiology.org
Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …
control almost all aspects of a cell's life and death. These lipids gained tremendous research …
[HTML][HTML] PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome
Membrane fusion and fission events in intracellular trafficking are controlled by both
intraluminal Ca2+ release and phosphoinositide (PIP) signalling. However, the molecular …
intraluminal Ca2+ release and phosphoinositide (PIP) signalling. However, the molecular …
International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family
Transient receptor potential (TRP) channels are a large family of ion channel proteins,
surpassed in number in mammals only by voltage-gated potassium channels. TRP channels …
surpassed in number in mammals only by voltage-gated potassium channels. TRP channels …
Structure of the receptor-activated human TRPC6 and TRPC3 ion channels
Q Tang, W Guo, L Zheng, JX Wu, M Liu, X Zhou… - Cell research, 2018 - nature.com
TRPC6 and TRPC3 are receptor-activated nonselective cation channels that belong to the
family of canonical transient receptor potential (TRPC) channels. They are activated by …
family of canonical transient receptor potential (TRPC) channels. They are activated by …
mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling
VS Rodrik-Outmezguine, S Chandarlapaty, NC Pagano… - Cancer discovery, 2011 - AACR
Abstract mTOR kinase inhibitors block mTORC1 and mTORC2 and thus do not cause the
mTORC2 activation of AKT observed with rapamycin. We now show, however, that these …
mTORC2 activation of AKT observed with rapamycin. We now show, however, that these …
[HTML][HTML] TRPV1 channels are intrinsically heat sensitive and negatively regulated by phosphoinositide lipids
E Cao, JF Cordero-Morales, B Liu, F Qin, D Julius - Neuron, 2013 - cell.com
The capsaicin receptor, TRPV1, is regulated by phosphatidylinositol-4, 5-bisphosphate (PIP
2), although the precise nature of this effect (ie, positive or negative) remains controversial …
2), although the precise nature of this effect (ie, positive or negative) remains controversial …
PIP2 Is a Necessary Cofactor for Ion Channel Function: How and Why?
BC Suh, B Hille - Annu. Rev. Biophys., 2008 - annualreviews.org
Phosphatidylinositol 4, 5-bisphosphate (PIP2) is a minority phospholipid of the inner leaflet
of plasma membranes. Many plasma membrane ion channels and ion transporters require …
of plasma membranes. Many plasma membrane ion channels and ion transporters require …
[HTML][HTML] The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity
TRPV1 plays a key role in nociception, as it is activated by heat, low pH, and ligands such as
capsaicin, leading to a burning pain sensation. We describe the structure of the cytosolic …
capsaicin, leading to a burning pain sensation. We describe the structure of the cytosolic …