For more than 25 years, it has been widely appreciated that Ca2+ influx is essential to
trigger T‐lymphocyte activation. Patch clamp analysis, molecular identification, and …

T cell activation and function require a structured engagement of antigen-presenting cells.
These cell contacts are characterized by two distinct dynamics in vivo: transient contacts …

Autoreactive memory T lymphocytes are implicated in the pathogenesis of autoimmune
diseases. Here we demonstrate that disease-associated autoreactive T cells from patients …

The function of T cells is critically dependent on their ability to generate metabolic building
blocks to fulfil energy demands for proliferation and consecutive differentiation into various T …

Abstract The voltage-gated Kv1. 3 channel and the Ca 2+-activated IKCa1 K+ channel are
expressed in T cells in a distinct pattern that depends on the state of lymphocyte activation …

Electrophysiological and pharmacological studies coupled with molecular identification
have revealed a unique network of ion channels—Kv1. 3, KCa3. 1, CRAC (Orai1+ Stim1) …

A variety of ion channels, including members of all major ion channel families, have been
shown to be regulated by changes in the level of membrane cholesterol and partition into …

The immunological synapse (IS) has proved to be a stimulating concept, particularly in
provoking discussion on the similarity of intercellular communication controlling disparate …

For efficient development of an immune response, T lymphocytes require long-lasting
calcium influx through calcium release-activated calcium (CRAC) channels and the …

Potassium channels are a diverse group of pore-forming transmembrane proteins that
selectively facilitate potassium flow through an electrochemical gradient. They participate in …