Immune checkpoint blockade (ICB) therapies have achieved clinical benefit, but most
'immune-cold'solid tumors are not responsive. The diversity of immune evasion mechanisms …

Dying mammalian cells emit numerous signals that interact with the host to dictate the
immunological correlates of cellular stress and death. In the absence of reactive antigenic …

Immunogenic cell death significantly contributes to the success of anti-cancer therapies, but
immunogenicity of different cell death modalities widely varies. Ferroptosis, a form of cell …

Damage-associated molecular patterns (DAMPs) are endogenous molecules which foment
inflammation and are associated with disorders in sepsis and cancer. Thus, therapeutically …

Tumor metastases are considered the leading cause of cancer-associated deaths. While
clinically applied drugs have demonstrated to efficiently remove the primary tumor …

Abstract cGAS-STING pathway is a key DNA-sensing machinery and emerges as a
promising target to overcome the immunoresistance of solid tumors. Here we describe a …

The immunosuppression and immune escape of current immunotherapy result in low
efficacy, and ferroptosis is greatly restricted by the low reactive oxygen species (ROS) …

Tumor cells undergoing immunogenic cell death (ICD) release immunogenic damage-
associated molecular patterns (DAMPs) to trigger a long-term protective antitumor response …

The cancer‐immune cycle conceptualized the mechanisms of driving T cell responses to
tumors, but w as limited by immunological ignorance elicited by tumor inherent …

Ferroptosis is a form of iron‐dependent regulated cell death characterized by the
accumulation of toxic lipid peroxides, particularly in the plasma membrane, leading to lytic …