Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

Primary sclerosing cholangitis (PSC) offers unique opportunities to explore the gut–liver axis
owing to the close association between liver disease and colonic inflammation. It is well …

Primary sclerosing cholangitis (PSC) was declared one of the biggest unmet needs in
hepatology during International Liver Congress 2016 in Berlin. Since then, not much has …

Gut dysbiosis has been reported in chronic hepatitis B (CHB) infection, however its role in
CHB progression and antiviral treatment remains to be clarified. Herein, the present study …

Autoimmune liver diseases are a group of immune-mediated liver diseases with three
distinct entities, including autoimmune hepatitis, primary biliary cholangitis, and primary …

Gallic acid (GA) is a natural polyphenolic compound with many health benefits. To assess
the potential risk of long-term consumption of GA to gut health, healthy dogs were fed a …

Primary sclerosing cholangitis (PSC) is an autoimmune disease characterized by chronic
cholestasis, a persistent inflammation of the bile ducts that leads to sclerotic occlusion and …

Deep vein thrombosis (DVT) is a leading cause of morbidity and mortality after trauma. Here,
we integrate plasma metabolomics and proteomics to evaluate the metabolic alterations and …

The gut microbiome is associated with hepatitis B virus (HBV)-induced liver disease, which
progresses from chronic hepatitis B, to liver cirrhosis, and eventually to hepatocellular …

Abstract IgG4-related cholangitis (IRC) is the major hepatobiliary manifestation of IgG4-
related disease (IgG4-RD), a systemic fibroinflammatory disorder. The pathogenesis of IgG4 …