Disturbances in the glutamatergic system have been increasingly documented in several
neuropsychiatric disorders, including autism spectrum disorder (ASD). Glutamate-centered …

L-glutamate (L-Glu) is a nonessential amino acid, but an extensively utilised excitatory
neurotransmitter with critical roles in normal brain function. Aberrant accumulation of L-Glu …

In the mammalian brain, glutamate is regarded to be the primary excitatory neurotransmitter
due to its widespread distribution and wide range of metabolic functions. Glutamate plays …

N-methyl-d-aspartate receptors (NMDARs) are ion channels that respond to the
neurotransmitter glutamate, playing a crucial role in the permeability of calcium ions and …

In this review, we focus on prenatal opioid exposure (POE) given the significant concern for
the mental health outcomes of children with parents affected by opioid use disorder (OUD) in …

Background Glutamate and glutamine are the most abundant amino acids in the blood and
play a crucial role in cell survival in the nervous system. Various transporters found in cell …

Background Depression is a heterogeneous disorder with high morbidity and disability rates
that poses serious problems regarding mental health care. It is now well established that N …

The neuroinflammatory process characterizing multiple sclerosis (MS) is associated with
changes in excitatory synaptic transmission and altered central concentrations of the primary …

Neonatal anesthesia, while often essential for surgeries or imaging procedures, is
accompanied by significant risks to redox balance in the brain due to the relatively weak …

Sleep is essential for brain development and overall health, particularly in children with
neurodevelopmental disorders (NDDs). Sleep disruptions can considerably impact brain …