Harmonizing the neurobiology and treatment of obsessive-compulsive disorder
WK Goodman, EA Storch… - American Journal of …, 2021 - Am Psychiatric Assoc
Obsessive-compulsive disorder (OCD) is a common, chronic, and oftentimes disabling
disorder. The only established first-line treatments for OCD are exposure and response …
disorder. The only established first-line treatments for OCD are exposure and response …
Searching for an anchor in an unpredictable world: A computational model of obsessive compulsive disorder.
In this article, we develop a computational model of obsessive–compulsive disorder (OCD).
We propose that OCD is characterized by a difficulty in relying on past events to predict the …
We propose that OCD is characterized by a difficulty in relying on past events to predict the …
[HTML][HTML] Mechanisms of pathogenesis and environmental moderators in preclinical models of compulsive-like behaviours
Obsessive-compulsive and related disorders (OCRD) is an emergent class of psychiatric
illnesses that contributes substantially to the global mental health disease burden. In …
illnesses that contributes substantially to the global mental health disease burden. In …
Ketamine increases activity of a fronto-striatal projection that regulates compulsive behavior in SAPAP3 knockout mice
Abstract Obsessive-Compulsive Disorder (OCD), characterized by intrusive thoughts
(obsessions) and repetitive behaviors (compulsions), is associated with dysfunction in fronto …
(obsessions) and repetitive behaviors (compulsions), is associated with dysfunction in fronto …
Repeated chemogenetic activation of dopaminergic neurons induces reversible changes in baseline and amphetamine-induced behaviors
MO Chohan, H Fein, S Mirro, KC O'Reilly… - …, 2023 - Springer
Rationale Repeated chemogenetic stimulation is often employed to study circuit function
and behavior. Chronic or repeated agonist administration can result in homeostatic …
and behavior. Chronic or repeated agonist administration can result in homeostatic …
Pharmacotherapeutic strategies and new targets in OCD
C Pittenger - The Neurobiology and Treatment of OCD: Accelerating …, 2021 - Springer
Effective pharmacological and psychotherapeutic treatments are well established for
obsessive-compulsive disorder (OCD). Serotonin reuptake inhibitors (SRIs) are first-line …
obsessive-compulsive disorder (OCD). Serotonin reuptake inhibitors (SRIs) are first-line …
Distinct patterns of abnormal lateral orbitofrontal cortex activity during compulsive grooming and reversal learning normalize after fluoxetine
Background Patients with obsessive-compulsive disorder (OCD) display disrupted
performance and abnormal lateral orbitofrontal cortex (LOFC) activity during reversal …
performance and abnormal lateral orbitofrontal cortex (LOFC) activity during reversal …
Abnormalities in static and dynamic intrinsic neural activity and neurotransmitters in first-episode OCD
Q Tao, J Dang, H Guo, M Zhang, X Niu, Y Kang… - Journal of Affective …, 2024 - Elsevier
Background Obsessive-compulsive disorder (OCD) is a disabling disorder in which the
temporal variability of regional brain connectivity is not well understood. The aim of this …
temporal variability of regional brain connectivity is not well understood. The aim of this …
Disruption of prepulse inhibition is associated with compulsive behavior severity and nucleus accumbens dopamine receptor changes in Sapap3 knockout mice
EE Manning, AY Wang, LM Saikali, AS Winner… - Scientific Reports, 2021 - nature.com
Obsessive compulsive disorder (OCD) is associated with disruption of sensorimotor gating,
which may contribute to difficulties inhibiting intrusive thoughts and compulsive rituals …
which may contribute to difficulties inhibiting intrusive thoughts and compulsive rituals …