Networks of molecular regulators are often the primary objects of focus in the study of gene
regulation, with the machinery of protein synthesis tacitly relegated to the background …

Why do evolutionarily distinct microorganisms display similar physiological behaviours?
Why are transitions from high-ATP yield to low (er)-ATP yield metabolisms so widespread …

Timely adaptation to nutrient downshift is crucial for bacteria to maintain fitness during feast
and famine cycle in the natural niche. However, the molecular mechanism that ensures the …

Many cellular activities in bacteria are organized according to their growth rate. The notion
that ppGpp measures the cell's growth rate is well accepted in the field of bacterial …

Bacterial fitness depends on adaptability to changing environments. In rich growth medium,
which is replete with amino acids, Escherichia coli primarily expresses protein synthesis …

Over the past decades, our understanding of microbial metabolism has increased
dramatically. Metabolomics, a family of techniques that are used to measure the quantities of …

Acetate, a major by‐product of glycolytic metabolism in Escherichia coli and many other
microorganisms, has long been considered a toxic waste compound that inhibits microbial …

Arsenic methylation is the microbe-mediated transformation of inorganic As into methylated
species, an important component of the biogeochemical arsenic cycle in rice paddies. Prior …

Adaptive laboratory evolution experiments provide a controlled context in which the
dynamics of selection and adaptation can be followed in real-time at the single-nucleotide …

Microbial catalysts must partition incoming substrate between the synthesis of biomass and
the synthesis of a desired product. Although biomass synthesis generates more catalyst and …