The current role of the heavy/light chain assay in the diagnosis, prognosis and monitoring of multiple myeloma: an evidence-based approach

R Ríos-Tamayo, N Puig, M Algarín… - Diagnostics, 2021 - mdpi.com
Despite tremendous progress being made in recent years, multiple myeloma (MM) remains
a challenging disease. The laboratory plays a critical role in the overall management of …

Risk stratification in multiple myeloma

MGM Ooi, S de Mel, WJ Chng - Current hematologic malignancy reports, 2016 - Springer
There are many prognostic variables in multiple myeloma and the difficulty is in deciding
which is truly significant. The widely used International Staging System (ISS) does not …

Heavy+ light chain monitoring correlates with clinical outcome in multiple myeloma patients

M Michallet, C Chapuis-Cellier, T Dejoie, C Lombard… - Leukemia, 2018 - nature.com
Novel anti-myeloma agents have improved patient response rates, which are historically
based on reductions of the M-protein. These methods can be inaccurate for quantifying M …

Heavy/light chain assay in the monitoring of multiple myeloma

HY Ting, P Sthaneshwar, PC Bee, H Shanmugam… - Pathology, 2019 - Elsevier
Serum protein (SPE) and immunofixation electrophoresis (IFE) have been extensively
validated for the routine use of identifying, characterising and quantifying monoclonal …

[HTML][HTML] A novel approach for more precise quantification of M-protein using variables derived from immunosubtraction electropherogram and associated biochemistry …

D Šegulja, D Matišić, K Barišić, D Rogić - Biochemia medica, 2022 - hrcak.srce.hr
Sažetak IntroductionDue to limitations in currently used methodologies, the widely
acknowledged approach for quantifying M-protein (MP) is not available. If employed as a …

[HTML][HTML] 血清IgD 定量检测在IgD 型多发性骨髓瘤患者疗效评估中的价值

贺婕, 张慧, 姜华, 曾添美, 常洪… - Chinese Journal of …, 2016 - ncbi.nlm.nih.gov
血清IgD定量检测在IgD型多发性骨髓瘤患者疗效评估中的价值- PMC Back to Top Skip to main
content NIH NLM Logo Access keys NCBI Homepage MyNCBI Homepage Main Content Main …

Quantification of β-region IgA monoclonal proteins – should we include immunochemical Hevylite® measurements? Point

JAR Evans, EL Jenner, HD Carr Smith… - Clinical Chemistry and …, 2016 - degruyter.com
Accurate measurement of IgA monoclonal proteins presents a significant challenge to
laboratory staff. IgA heavy/light chain (Hevylite, HLC) analysis is an alternative methodology …

[HTML][HTML] 重轻链检测在多发性骨髓瘤疗效评价中的意义

于晓晨, 苏薇, 庄俊玲 - Chinese Journal of Hematology, 2018 - ncbi.nlm.nih.gov
重轻链检测在多发性骨髓瘤疗效评价中的意义- PMC Back to Top Skip to main content NIH
NLM Logo Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation …

[PDF][PDF] Verification study of free light chains assays on reagent-optimized analysers

D Šegulja, D Matišić, K Barišić, D Rogić - Biochemia medica, 2019 - hrcak.srce.hr
Original articles Page 1 https://doi.org/10.11613/BM.2019.030709 Biochem Med (Zagreb)
2019;29(3):030709 1 Abstract Introduction:Our aim was to compare analytical specifications of …

Detection of the value of consecutive serum total light chain (sTLC) in patients diagnosed with diffuse large B cell lymphoma

L Zhai, Y Zhao, S Peng, K Zhu, R Yu, H Chen, T Lin… - Annals of …, 2016 - Springer
There are limited data on serum total light chain (sTLC) in lymphoma and its relative role on
the outcome of diffuse large B cell lymphoma (DLBCL) patients. Blood samples from 46 …