Bacterial chromosome organization and segregation

A Badrinarayanan, TBK Le… - Annual review of cell and …, 2015 - annualreviews.org
If fully stretched out, a typical bacterial chromosome would be nearly 1 mm long,
approximately 1,000 times the length of a cell. Not only must cells massively compact their …

Subcellular organization: a critical feature of bacterial cell replication

IV Surovtsev, C Jacobs-Wagner - Cell, 2018 - cell.com
Spatial organization is a hallmark of all living systems. Even bacteria, the smallest forms of
cellular life, display defined shapes and complex internal organization, showcasing a highly …

[HTML][HTML] The bacterial cytoplasm has glass-like properties and is fluidized by metabolic activity

BR Parry, IV Surovtsev, MT Cabeen, CS O'Hern… - Cell, 2014 - cell.com
The physical nature of the bacterial cytoplasm is poorly understood even though it
determines cytoplasmic dynamics and hence cellular physiology and behavior. Through …

Evidence for a DNA-relay mechanism in ParABS-mediated chromosome segregation

HC Lim, IV Surovtsev, BG Beltran, F Huang… - elife, 2014 - elifesciences.org
The widely conserved ParABS system plays a major role in bacterial chromosome
segregation. How the components of this system work together to generate translocation …

Bacterial chromosome segregation by the ParABS system

ASB Jalal, TBK Le - Open biology, 2020 - royalsocietypublishing.org
Proper chromosome segregation during cell division is essential in all domains of life. In the
majority of bacterial species, faithful chromosome segregation is mediated by the tripartite …

Plasmid partition mechanisms

JC Baxter, BE Funnell - Plasmids: biology and impact in …, 2015 - Wiley Online Library
The stable maintenance of low‐copy‐number plasmids in bacteria is actively driven by
partition mechanisms that are responsible for the positioning of plasmids inside the cell …

ParB spreading on DNA requires cytidine triphosphate in vitro

ASB Jalal, NT Tran, TBK Le - Elife, 2020 - elifesciences.org
In all living organisms, it is essential to transmit genetic information faithfully to the next
generation. The SMC-ParAB-parS system is widely employed for chromosome segregation …

A propagating ATPase gradient drives transport of surface-confined cellular cargo

AG Vecchiarelli, KC Neuman… - Proceedings of the …, 2014 - National Acad Sciences
The faithful segregation of duplicated genetic material into daughter cells is critical to all
organisms. In many bacteria, the segregation of chromosomes involves transport of …

Connecting the dots: key insights on ParB for chromosome segregation from single-molecule studies

M Tišma, J Kaljević, S Gruber, TBK Le… - FEMS Microbiology …, 2024 - academic.oup.com
Bacterial cells require DNA segregation machinery to properly distribute a genome to both
daughter cells upon division. The most common system involved in chromosome and …

Relief of ParB autoinhibition by parS DNA catalysis and recycling of ParB by CTP hydrolysis promote bacterial centromere assembly

H Antar, YM Soh, S Zamuner, FP Bock, A Anchimiuk… - Science …, 2021 - science.org
Three-component ParABS systems are widely distributed factors for plasmid partitioning and
chromosome segregation in bacteria. ParB acts as adaptor protein between the 16–base …