Caught in vicious circles: a perspective on dynamic feed-forward loops driving oxidative stress in schizophrenia

M Cuenod, P Steullet, JH Cabungcal, D Dwir… - Molecular …, 2022 - nature.com
A growing body of evidence has emerged demonstrating a pathological link between
oxidative stress and schizophrenia. This evidence identifies oxidative stress as a …

Parvalbumin interneuron vulnerability and brain disorders

JB Ruden, LL Dugan, C Konradi - Neuropsychopharmacology, 2021 - nature.com
Parvalbumin-expressing interneurons (PV-INs) are highly vulnerable to stressors and have
been implicated in many neuro-psychiatric diseases such as schizophrenia, Alzheimer's …

Epigenetic mechanisms in schizophrenia and other psychotic disorders: a systematic review of empirical human findings

L Smigielski, V Jagannath, W Rössler, S Walitza… - Molecular …, 2020 - nature.com
Schizophrenia and other psychotic disorders are highly debilitating psychiatric conditions
that lack a clear etiology and exhibit polygenic inheritance underlain by pleiotropic genes …

Are the epigenetic changes predictive of therapeutic efficacy for psychiatric disorders? A translational approach towards novel drug targets

V Micale, M Di Bartolomeo, S Di Martino, T Stark… - Pharmacology & …, 2023 - Elsevier
The etiopathogenesis of mental disorders is not fully understood and accumulating evidence
support that clinical symptomatology cannot be assigned to a single gene mutation, but it …

DNA methylation and schizophrenia: current literature and future perspective

T Magwai, KB Shangase, FO Oginga, B Chiliza… - Cells, 2021 - mdpi.com
Schizophrenia is a neuropsychiatric disorder characterized by dissociation of thoughts, idea,
identity, and emotions. It has no central pathophysiological mechanism and precise …

Can epigenetics shine a light on the biological pathways underlying major mental disorders?

L Alameda, G Trotta, H Quigley, V Rodriguez… - Psychological …, 2022 - cambridge.org
A significant proportion of the global burden of disease can be attributed to mental illness.
Despite important advances in identifying risk factors for mental health conditions, the …

Cytosolic Ca2+ buffers are inherently Ca2+ signal modulators

B Schwaller - Cold Spring Harbor perspectives in biology, 2020 - cshperspectives.cshlp.org
For precisely regulating intracellular Ca2+ signals in a time-and space-dependent manner,
cells make use of various components of the “Ca2+ signaling toolkit,” including Ca2+ entry …

Decreased oligodendrocyte number in hippocampal subfield CA4 in schizophrenia: a replication study

A Schmitt, L Tatsch, A Vollhardt, T Schneider-Axmann… - Cells, 2022 - mdpi.com
Hippocampus-related cognitive deficits in working and verbal memory are frequent in
schizophrenia, and hippocampal volume loss, particularly in the cornu ammonis (CA) …

[HTML][HTML] Early-life stress effects on BDNF DNA methylation in first-episode psychosis and in rats reared in isolation

HA Fachim, F Corsi-Zuelli, CM Loureiro… - Progress in Neuro …, 2021 - Elsevier
Stressful events during early-life are risk factors for psychiatric disorders. Brain-derived
neurotrophic factor (BDNF) is implicated in psychosis pathophysiology and deficits in BDNF …

An altered global DNA methylation status in women with depression

E Reszka, E Jabłońska, M Lesicka, E Wieczorek… - Journal of psychiatric …, 2021 - Elsevier
Sparse studies have shown that specific biomarkers of a global DNA methylation status may
be related to various mental diseases and states, including: bipolar disorder (BD), anxiety …