Calciprotein particles: balancing mineral homeostasis and vascular pathology

AG Kutikhin, L Feenstra, AE Kostyunin… - … , and vascular biology, 2021 - Am Heart Assoc
Hypercalcemia and hyperphosphatemia associate with an elevated risk of cardiovascular
events, yet the pathophysiological basis of this association is unclear. Disturbed mineral …

Inflammation: a putative link between phosphate metabolism and cardiovascular disease

J Voelkl, D Egli-Spichtig, I Alesutan… - Clinical Science, 2021 - portlandpress.com
Dietary habits in the western world lead to increasing phosphate intake. Under physiological
conditions, extraosseous precipitation of phosphate with calcium is prevented by a mineral …

Role of Chronic Kidney Disease (CKD)–Mineral and Bone Disorder (MBD) in the Pathogenesis of Cardiovascular Disease in CKD

S Yamada, T Nakano - Journal of atherosclerosis and thrombosis, 2023 - jstage.jst.go.jp
Cardiovascular disease (CVD) is the leading cause of death in patients with chronic kidney
disease (CKD). Multiple factors account for the increased incidence of cardiovascular …

Exposure to zinc oxide nanoparticles (ZnO-NPs) induces cardiovascular toxicity and exacerbates pathogenesis–Role of oxidative stress and MAPK signaling

M Nagarajan, GB Maadurshni, GK Tharani… - Chemico-Biological …, 2022 - Elsevier
The precise toxico-pathogenic effects of zinc oxide nanoparticles (ZnO-NPs) on the
cardiovascular system under normal and cardiovascular disease (CVD) risk factor milieu are …

Serum calcification propensity and the risk of cardiovascular and all-cause mortality in the general population: the PREVEND study

C Eelderink, CA te Velde-Keyzer… - … , and vascular biology, 2020 - Am Heart Assoc
Objective: Vascular calcification contributes to the cause of cardiovascular disease. The
calciprotein particle maturation time (T50) in serum, a measure of calcification propensity …

Interplay between gut microbiota, bone health and vascular calcification in chronic kidney disease

FG Rodrigues, MS Ormanji, IP Heilberg… - European Journal of …, 2021 - Wiley Online Library
Deregulations in gut microbiota may play a role in vascular and bone disease in chronic
kidney disease (CKD). As glomerular filtration rate declines, the colon becomes more …

Magnesium Administration in Chronic Kidney Disease

EA Vermeulen, MG Vervloet - Nutrients, 2023 - mdpi.com
Awareness of the clinical relevance of magnesium in medicine has increased over the last
years, especially for people with chronic kidney disease (CKD), due to magnesium's role in …

Inflammation and gut dysbiosis as drivers of CKD–MBD

P Evenepoel, P Stenvinkel, C Shanahan… - Nature Reviews …, 2023 - nature.com
Abstract Two decades ago, Kidney Disease: Improving Global Outcomes coined the term
chronic kidney disease–mineral and bone disorder (CKD–MBD) to describe the syndrome of …

The biology of vascular calcification

D Quaglino, F Boraldi, FD Lofaro - … review of cell and molecular biology, 2020 - Elsevier
Vascular calcification (VC), characterized by different mineral deposits (ie, carbonate apatite,
whitlockite and hydroxyapatite) accumulating in blood vessels and valves, represents a …

The emerging role of magnesium in CKD

Y Sakaguchi - Clinical and experimental nephrology, 2022 - Springer
Increasing evidence has suggested a clinical relevance of magnesium in the context of
vascular calcification and mortality among patients with CKD. Hypomagnesemia is not rare …