Tumor cells do not exist in isolation in vivo, and carcinogenesis depends on the surrounding
tumor microenvironment (TME), composed of a myriad of cell types and biophysical and …

Tumors are one of the main causes of death in humans. The development of safe and
effective methods for early diagnosis and treatment of tumors is a difficult problem that needs …

Antibody–drug conjugates (ADCs) constitute a relatively new group of anticancer agents,
whose first appearance took place about two decades ago, but a renewed interest occurred …

Cancer-associated fibroblasts (CAFs) are major component of tumor microenvironment
(TME), which plays crucial roles in tumor growth, invasion and metastasis; however, the …

Background Cancer-associated fibroblasts (CAFs), as the activated stroma cells, contribute
to tumor progression via the release of cytokines, growth factors, and hormones. However …

Acute myeloid leukemia (AML) comprises a multifarious and heterogeneous array of
illnesses characterized by the anomalous proliferation of myeloid cells in the bone marrow …

Fibroblasts are the most abundant stromal constituents of the tumour microenvironment in
primary as well as metastatic colorectal cancer (CRC). Their supportive effect on tumour …

With the rapid clinical development of immune checkpoint inhibitors (ICIs), the standard of
care in cancer management has evolved rapidly. However, immunotherapy is not currently …

Cancer-associated fibroblasts (CAFs) are the major components of the tumor
microenvironment and are related to tumor proliferation, metastasis, relapse, and drug …

Aging is a natural intrinsic process associated with the loss of fibrous tissue, a slower cell
turnover, and a reduction in immune system competence. In the skin, the continuous …