Antimicrobial peptides: diversity, mechanism of action and strategies to improve the activity and biocompatibility in vivo

P Kumar, JN Kizhakkedathu, SK Straus - Biomolecules, 2018 - mdpi.com
Antibiotic resistance is projected as one of the greatest threats to human health in the future
and hence alternatives are being explored to combat resistance. Antimicrobial peptides …

[HTML][HTML] Reassessing the host defense peptide landscape

EF Haney, SK Straus, REW Hancock - Frontiers in chemistry, 2019 - frontiersin.org
Current research has demonstrated that small cationic amphipathic peptides have strong
potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and …

Antioxidant and antimicrobial peptides derived from food proteins

G López-García, O Dublan-García, D Arizmendi-Cotero… - Molecules, 2022 - mdpi.com
Recently, the demand for food proteins in the market has increased due to a rise in
degenerative illnesses that are associated with the excessive production of free radicals and …

Peptides with dual antimicrobial and anticancer activities

MR Felício, ON Silva, S Gonçalves, NC Santos… - Frontiers in …, 2017 - frontiersin.org
In recent years, the number of people suffering from cancer and multi-resistant infections has
increased, such that both diseases are already seen as current and future major causes of …

How membrane-active peptides get into lipid membranes

MA Sani, F Separovic - Accounts of chemical research, 2016 - ACS Publications
Conspectus The structure–function relationship for a family of antimicrobial peptides (AMPs)
from the skin of Australian tree frogs is discussed and compared with that of peptide toxins …

Antimicrobial peptides: challenging journey to the pharmaceutical, biomedical, and cosmeceutical use

A Mazurkiewicz-Pisarek, J Baran, T Ciach - International journal of …, 2023 - mdpi.com
Antimicrobial peptides (AMPs), or host defence peptides, are short proteins in various life
forms. Here we discuss AMPs, which may become a promising substitute or adjuvant in …

The chemistry and biological activities of peptides from amphibian skin secretions

X Xu, R Lai - Chemical reviews, 2015 - ACS Publications
Amphibian skin is directly exposed to different environments. Amphibians interact with
environmental factors including microorganisms, parasites, predators, and physical factors …

Recurrent neural network model for constructive peptide design

AT Muller, JA Hiss, G Schneider - Journal of chemical information …, 2018 - ACS Publications
We present a generative long short-term memory (LSTM) recurrent neural network (RNN) for
combinatorial de novo peptide design. RNN models capture patterns in sequential data and …

[HTML][HTML] Studies on anticancer activities of antimicrobial peptides

DW Hoskin, A Ramamoorthy - Biochimica et Biophysica Acta (BBA) …, 2008 - Elsevier
In spite of great advances in cancer therapy, there is considerable current interest in
developing anticancer agents with a new mode of action because of the development of …

[HTML][HTML] Membrane-active host defense peptides–challenges and perspectives for the development of novel anticancer drugs

S Riedl, D Zweytick, K Lohner - Chemistry and physics of lipids, 2011 - Elsevier
Although much progress has been achieved in the development of cancer therapies in
recent decades, problems continue to arise particularly with respect to chemotherapy due to …