Hepatic encephalopathy (HE) following acute and chronic liver failure is defined as a
complex of neuropsychiatric abnormalities, such as discrete personal changes, sleep …

The literature provides compelling evidence pointing to tight metabolic interactions between
retinoids and xenobiotics. These are extensive and important for understanding xenobiotic …

Hepatic stellate cells (HSCs) are non-parenchymal liver cells that characteristically contain
multiple retinoid (vitamin A)-containing lipid droplets. In this study, we addressed the …

Environmental exposure to polychlorinated biphenyls (PCBs) is associated with an
increased risk of incidence of metabolic disease, however the molecular mechanisms …

This study investigated the potential hepatoprotective effect of oligoribonucleotides-d-
mannitol complexes (ORNs-dM) against thioacetamide (TAA)-induced hepatotoxicity in …

Abstract Objectives Vitamins A and D provided protection from xenobiotic-induced liver
injury in previous animal studies. We conducted a post hoc analysis of our previous …

Animal studies are typically utilized to understand the complex mechanisms associated with
toxicant-induced hepatotoxicity. Among the alternative approaches to animal studies, in vitro …

The neurological involvement in acute liver failure (ALF) is characterized by arousal
impairment with progression to coma. There is a growing body of evidence that …

Exposure to the toxin thioacetamide (TAA) causes acute hepatic encephalopathy (HE),
changes in the functioning of systemic organs, and an imbalance in a number of energy …

Thioacetamide (TAA), a widely employed hepatotoxic substance, has gained significant
traction in the induction of liver failure disease models. Upon administration of TAA to …