BACKGROUND The idea that memory is stored as enduring changes in the brain dates
back at least to the time of Plato and Aristotle (circa 350 BCE), but its scientific articulation …

Highlights•Recurrent connectivity is anatomically and functionally prevalent in fly memory
circuits.•Sustained reverberant activity is necessary for memory consolidation.•Feedforward …

Making inferences about the computations performed by neuronal circuits from synapse-
level connectivity maps is an emerging opportunity in neuroscience. The mushroom body …

Associating stimuli with positive or negative reinforcement is essential for survival, but a
complete wiring diagram of a higher-order circuit supporting associative memory has not …

Understanding memory formation, storage and retrieval requires knowledge of the
underlying neuronal circuits. In Drosophila, the mushroom body (MB) is the major site of …

Associating multiple sensory cues with objects and experience is a fundamental brain
process that improves object recognition and memory performance. However, neural …

The Drosophila brain contains a relatively simple circuit for forming Pavlovian associations,
yet it achieves many operations common across memory systems. Recent advances have …

Accurately predicting an outcome requires that animals learn supporting and conflicting
evidence from sequential experience. In mammals and invertebrates, learned fear …

The fruit fly can evaluate its energy state and decide whether to pursue food-related cues.
Here, we reveal that the mushroom body (MB) integrates hunger and satiety signals to …

Resource-seeking behaviours are ordinarily constrained by physiological needs and threats
of danger, and the loss of these controls is associated with pathological reward seeking …