Autism spectrum disorder and schizophrenia: An updated conceptual review
A Jutla, J Foss‐Feig… - Autism …, 2022 - Wiley Online Library
Autism spectrum disorder (ASD) and schizophrenia (SCZ) are separate disorders, with
distinct clinical profiles and natural histories. ASD, typically diagnosed in childhood, is …
distinct clinical profiles and natural histories. ASD, typically diagnosed in childhood, is …
The genetic architecture of schizophrenia: review of large-scale genetic studies
H Kato, H Kimura, I Kushima, N Takahashi… - Journal of Human …, 2023 - nature.com
Schizophrenia is a complex and often chronic psychiatric disorder with high heritability.
Diagnosis of schizophrenia is still made clinically based on psychiatric symptoms; no …
Diagnosis of schizophrenia is still made clinically based on psychiatric symptoms; no …
Neurexin1α knockout rats display oscillatory abnormalities and sensory processing deficits back-translating key endophenotypes of psychiatric disorders
P Janz, M Bainier, S Marashli… - Translational …, 2022 - nature.com
Neurexins are presynaptic transmembrane proteins crucial for synapse development and
organization. Deletion and missense mutations in all three Neurexin genes have been …
organization. Deletion and missense mutations in all three Neurexin genes have been …
Advances in neurexin studies and the emerging role of neurexin-2 in autism spectrum disorder
Over the past 3 decades, the prevalence of autism spectrum disorder (ASD) has increased
globally from 20 to 28 million cases making ASD the fastest-growing developmental …
globally from 20 to 28 million cases making ASD the fastest-growing developmental …
Metabolic contributions to neuronal deficits caused by genomic disruption of schizophrenia risk gene SETD1A
ZS Chong, ZJ Khong, SH Tay, SY Ng - Schizophrenia, 2022 - nature.com
Regulation of neuronal metabolism during early brain development is crucial for directing
synaptic plasticity and proper circuit formation. Alterations in neuronal glycolysis or …
synaptic plasticity and proper circuit formation. Alterations in neuronal glycolysis or …
Landscape of NRXN1 Gene Variants in Phenotypic Manifestations of Autism Spectrum Disorder: A Systematic Review
JN Cooper, J Mittal, A Sangadi, DL Klassen… - Journal of Clinical …, 2024 - mdpi.com
Background: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition
characterized by social communication challenges and repetitive behaviors. Recent …
characterized by social communication challenges and repetitive behaviors. Recent …
Bridging the translational gap: what can synaptopathies tell us about autism?
CJ Molloy, J Cooke, NJF Gatford… - Frontiers in Molecular …, 2023 - frontiersin.org
Multiple molecular pathways and cellular processes have been implicated in the
neurobiology of autism and other neurodevelopmental conditions. There is a current focus …
neurobiology of autism and other neurodevelopmental conditions. There is a current focus …
[HTML][HTML] Deciphering the role of precursor miR-12136 and miR-8485 in the progression of intellectual disability (ID)
P Garg, F Jamal, P Srivastava - IBRO neuroscience reports, 2022 - Elsevier
The short, non-coding RNAs known as miRNA modulate the expression of human protein-
coding genes. About 90% of genes in humans are controlled by the expression of miRNA …
coding genes. About 90% of genes in humans are controlled by the expression of miRNA …
Single nucleotide variations encoding missense mutations in G protein‐coupled receptors may contribute to autism
ET van der Westhuizen - British Journal of Pharmacology, 2024 - Wiley Online Library
Autism is a neurodevelopmental condition with a range of symptoms that vary in intensity
and severity from person to person. Genetic sequencing has identified thousands of genes …
and severity from person to person. Genetic sequencing has identified thousands of genes …
[HTML][HTML] Bi-allelic NRXN1α deletion in microglia derived from iPSC of an autistic patient increases interleukin-6 production and impairs supporting function on …
Autism spectrum disorder (ASD) is a set of heterogeneous neurodevelopmental conditions,
with a highly diverse genetic hereditary component, including altered neuronal circuits, that …
with a highly diverse genetic hereditary component, including altered neuronal circuits, that …