The function of the kidney, filtering blood and concentrating metabolic waste into urine, takes
place in an intricate and functionally elegant structure called the renal glomerulus. Normal …

Proteinuric kidney diseases are a group of disorders with diverse pathological mechanisms
associated with significant losses of protein in the urine. The glomerular filtration barrier …

The filtration of blood in the kidney which is crucial for mammalian life is determined by the
slit-diaphragm, a cell-cell junction between the foot processes of renal podocytes. The slit …

Background NPHS2 variants are the most common cause of steroid-resistant nephrotic
syndrome in children> 1 month old. Missense NPHS2 variants were reported to cause …

Primary forms of focal and segmental glomerulosclerosis (FSGS) are driven by circulating
factors that cause dysfunction or loss podocytes. Rare genetic forms of FSGS can be caused …

Stomatin is an ancient, widely expressed, oligomeric, monotopic membrane protein that is
associated with cholesterol-rich membranes/lipid rafts. It is part of the SPFH superfamily …

Introduction: The unique architecture of glomerular podocytes is integral to kidney filtration.
Interdigitating foot processes extend from the podocyte cell body, wrap around fenestrated …

Background Diseases of the kidney's glomerular filtration barrier are a leading cause of end
stage renal failure. Despite a growing understanding of genes involved in glomerular …

Abstract Inositol 1, 4, 5-trisphosphate receptors (IP 3 Rs) are large (∼ 300 kDa) proteins that
associate into tetrameric ion channels in the endoplasmic reticulum (ER) membrane …

Adhesion molecules of the immunoglobulin superfamily (IgSF) are essential for neuronal
synapse development across evolution and control various aspects of synapse formation …