Physiology of the tongue with emphasis on taste transduction

ME Doyle, HU Premathilake, Q Yao… - Physiological …, 2023 - journals.physiology.org
The tongue is a complex multifunctional organ that interacts and senses both interoceptively
and exteroceptively. Although it is easily visible to almost all of us, it is relatively …

A systematic review of the biological mediators of fat taste and smell

RB Jaime-Lara, BE Brooks, C Vizioli… - Physiological …, 2023 - journals.physiology.org
Taste and smell play a key role in our ability to perceive foods. Overconsumption of highly
palatable energy-dense foods can lead to increased caloric intake and obesity. Thus there is …

[HTML][HTML] Impact of conventional and atypical MAPKs on the development of metabolic diseases

T Kassouf, G Sumara - Biomolecules, 2020 - mdpi.com
The family of mitogen-activated protein kinases (MAPKs) consists of fourteen members and
has been implicated in regulation of virtually all cellular processes. MAPKs are divided into …

Preference for dietary fat: From detection to disease

AS Khan, R Keast, NA Khan - Progress in lipid research, 2020 - Elsevier
Recent advances in the field of taste physiology have clarified the role of different basic taste
modalities and their implications in health and disease and proposed emphatically that there …

Food protein structures, functionality and product development

ID Nwachukwu, RE Aluko - 2021 - books.rsc.org
The unique combinations of biological, nutritional and functional properties in proteins make
them important food ingredients with the capacity to provide a range of diverse and highly …

Orosensory detection of bitter in fat-taster healthy and obese participants: Genetic polymorphism of CD36 and TAS2R38

I Karmous, J Plesník, AS Khan, O Šerý, A Abid… - Clinical Nutrition, 2018 - Elsevier
Background & aims We assessed orosensory detection of a long-chain fatty acid, linoleic
acid (LA), and a bitter taste marker, 6-n-propylthiouracil (PROP), and correlated lipid-taster …

Mammalian taste cells express functional olfactory receptors

B Malik, N Elkaddi, J Turkistani, AI Spielman… - Chemical …, 2019 - academic.oup.com
The peripheral taste and olfactory systems in mammals are separate and independent
sensory systems. In the current model of chemosensation, gustatory, and olfactory receptors …

[HTML][HTML] Novel fat taste receptor agonists curtail progressive weight gain in obese male mice

AS Khan, A Hichami, B Murtaza… - Cellular and Molecular …, 2023 - Elsevier
Background & Aims The spontaneous preference for dietary lipids is principally regulated by
2 lingual fat taste receptors, CD36 and GPR120. Obese animals and most of human …

ERK1 and ERK2 activation modulates diet-induced obesity in mice

AS Khan, S Subramaniam, G Dramane, D Khelifi… - Biochimie, 2017 - Elsevier
Obesity is a worldwide problem, and dietary lipids play an important role in its pathogenesis.
Recently, Erk1 knock-out (ERK1−/−) mice have been shown to exhibit low preference for …

Dietary lipids as regulators of reward processes: multimodal integration matters

C Berland, DM Small, S Luquet… - Trends in Endocrinology & …, 2021 - cell.com
The abundance of energy-dense and palatable diets in the modern food environment tightly
contributes to the obesity pandemic. The reward circuit participates to the regulation of body …