Following periods of haematopoietic cell stress, such as after chemotherapy, radiotherapy,
infection and transplantation, patient outcomes are linked to the degree of immune …

There is an intense interplay between HIV and the immune system, and the literature is
replete with studies describing various immunological phenomena associated with HIV …

Immune checkpoint inhibitors (ICI) have transformed the therapeutic landscape in oncology.
However, ICI can induce uncommon life-threatening autoimmune T-cell-mediated …

Parallels between T cell kinetics in mice and men have fueled the idea that a young mouse
is a good model system for a young human, and an old mouse, for an elderly human. By …

This book grew out of a scientific review, originally published in Microbiological Reviews. It
has been updated and expanded-now citing more than 2100 references (100 pages of the …

The pathogenesis of human immunodeficiency virus has long been thought to center on a
gradual depletion of CD4+ T cells, with an average of 100 cells lost per microliter of blood …

Upon transmission to a new host, HIV targets CCR5+ CD4+ effector memory T cells,
resulting in acute, massive depletion of these cells from mucosal effector sites. This …

Background. Failure to normalize CD4+ T-cell numbers despite effective antiretroviral
therapy is an important problem in human immunodeficiency virus (HIV) infection. Methods …

Public T-cell responses, in which T cells bearing identical T-cell receptors (TCRs) are
observed to dominate the response to the same antigenic epitope in multiple individuals …

Peripheral T cell populations are maintained by production of naive T cells in the thymus,
clonal expansion of activated cells, cellular self-renewal (or homeostatic proliferation), and …