Molecular basis of atrial fibrillation pathophysiology and therapy: a translational perspective
Atrial fibrillation (AF) is a highly prevalent arrhythmia, with substantial associated morbidity
and mortality. There have been significant management advances over the past 2 decades …
and mortality. There have been significant management advances over the past 2 decades …
Atrial fibrillation: epidemiology, pathophysiology, and clinical outcomes
L Staerk, JA Sherer, D Ko, EJ Benjamin… - Circulation …, 2017 - Am Heart Assoc
The past 3 decades have been characterized by an exponential growth in knowledge and
advances in the clinical treatment of atrial fibrillation (AF). It is now known that AF genesis …
advances in the clinical treatment of atrial fibrillation (AF). It is now known that AF genesis …
JCS/JHRS 2020 guideline on pharmacotherapy of cardiac arrhythmias
K Ono, Y Iwasaki, M Akao, T Ikeda, K Ishii… - Circulation …, 2022 - jstage.jst.go.jp
The Japanese Circulation Society (JCS) published the “Guidelines for Pharmacological
Treatment of Arrhythmia” in 2004, and a revised edition was published in 2009. 1 Both …
Treatment of Arrhythmia” in 2004, and a revised edition was published in 2009. 1 Both …
Calcium signaling and cardiac arrhythmias
There has been a significant progress in our understanding of the molecular mechanisms by
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …
2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: executive summary: a report of the American College of Cardiology/American …
The recommendations listed in this document are, whenever possible, evidence based. An
extensive evidence review was conducted, focusing on 2006 through October 2012 and …
extensive evidence review was conducted, focusing on 2006 through October 2012 and …
2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task …
CT January, LS Wann, JS Alpert, H Calkins… - Journal of the American …, 2014 - jacc.org
The recommendations listed in this document are, whenever possible, evidence based. An
extensive evidence review was conducted, focusing on 2006 through October 2012 and …
extensive evidence review was conducted, focusing on 2006 through October 2012 and …
Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression
Atrial fibrillation (AF) is the most common clinically relevant arrhythmia and is associated
with increased morbidity and mortality. The incidence of AF is expected to continue to rise …
with increased morbidity and mortality. The incidence of AF is expected to continue to rise …
Pathophysiological mechanisms of atrial fibrillation: a translational appraisal
U Schotten, S Verheule, P Kirchhof… - Physiological …, 2011 - journals.physiology.org
Atrial fibrillation (AF) is an arrhythmia that can occur as the result of numerous different
pathophysiological processes in the atria. Some aspects of the morphological and …
pathophysiological processes in the atria. Some aspects of the morphological and …
Enhanced Sarcoplasmic Reticulum Ca2+ Leak and Increased Na+-Ca2+ Exchanger Function Underlie Delayed Afterdepolarizations in Patients With Chronic Atrial …
Background—Delayed afterdepolarizations (DADs) carried by Na+-Ca2+-exchange current
(INCX) in response to sarcoplasmic reticulum (SR) Ca2+ leak can promote atrial fibrillation …
(INCX) in response to sarcoplasmic reticulum (SR) Ca2+ leak can promote atrial fibrillation …
NLRP3 inflammasome is a key driver of obesity-induced atrial arrhythmias
Aims Obesity, an established risk factor of atrial fibrillation (AF), is frequently associated with
enhanced inflammatory response. However, whether inflammatory signaling is causally …
enhanced inflammatory response. However, whether inflammatory signaling is causally …