Mast cells in inflammation and disease: recent progress and ongoing concerns

SJ Galli, N Gaudenzio, M Tsai - Annual review of immunology, 2020 - annualreviews.org
Mast cells have existed long before the development of adaptive immunity, although they
have been given different names. Thus, in the marine urochordate Styela plicata, they have …

The ingenious mast cell: Contemporary insights into mast cell behavior and function

JS Dahlin, M Maurer, DD Metcalfe, G Pejler… - Allergy, 2022 - Wiley Online Library
Mast cells are (in) famous for their role in allergic diseases, but the physiological and
pathophysiological roles of this ingenious cell are still not fully understood. Mast cells are …

Endosomal signalling via exosome surface TGFβ-1

GV Shelke, Y Yin, SC Jang, C Lässer… - Journal of …, 2019 - Taylor & Francis
Extracellular vesicles such as exosomes convey biological messages between cells, either
by surface-to-surface interaction or by shuttling of bioactive molecules to a recipient cell's …

Recent advances in our understanding of mast cell activation–or should it be mast cell mediator disorders?

TC Theoharides, I Tsilioni, H Ren - Expert review of clinical …, 2019 - Taylor & Francis
Introduction: An increasing number of patients present with multiple symptoms affecting
many organs including the brain due to multiple mediators released by mast cells. These …

Mast cells, cortistatin, and its receptor, MRGPRX2, are linked to the pathogenesis of chronic prurigo

P Kolkhir, P Pyatilova, T Ashry, Q Jiao… - Journal of Allergy and …, 2022 - Elsevier
Background Chronic prurigo (CPG) is characterized by intensive itch and interactions
among nerves, neuropeptides, and mast cells (MCs). The role of some neuropeptides such …

[HTML][HTML] Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation

DK Kim, G Bandara, YE Cho, HD Komarow… - Nature …, 2021 - nature.com
Osteoporosis and other manifestations of bone disease are frequent in patients with
systemic mastocytosis (SM) in association with the presence of mast cell infiltrates in bone …

[HTML][HTML] Extracellular vesicles in organ fibrosis: mechanisms, therapies, and diagnostics

DR Brigstock - Cells, 2021 - mdpi.com
Fibrosis is the unrelenting deposition of excessively large amounts of insoluble interstitial
collagen due to profound matrigenic activities of wound-associated myofibroblasts during …

Yam-derived exosome-like nanovesicles stimulate osteoblast formation and prevent osteoporosis in mice

JH Hwang, YS Park, HS Kim, D Kim, SH Lee… - Journal of Controlled …, 2023 - Elsevier
Plants-releasing exosome-like nanovesicles (PENs) contain miRNA, bioactive lipids,
mRNAs, and proteins to exert antioxidant, anti-inflammatory, and regenerative activity …

Emerging mechanisms contributing to mast cell-mediated pathophysiology with therapeutic implications

GH Falduto, A Pfeiffer, A Luker, DD Metcalfe… - Pharmacology & …, 2021 - Elsevier
Mast cells are tissue-resident immune cells that play key roles in the initiation and
perpetuation of allergic inflammation, usually through IgE-mediated mechanisms. Mast cells …

[HTML][HTML] Intercellular communication between hepatic cells in liver diseases

K Sato, L Kennedy, S Liangpunsakul… - International journal of …, 2019 - mdpi.com
Liver diseases are perpetuated by the orchestration of hepatocytes and other hepatic non-
parenchymal cells. These cells communicate and regulate with each other by secreting …