Nonsteroidal anti-inflammatory drugs (NSAIDs) are probably the most common cause of
gastroduodenal injury in the United States today. Approximately half of patients who …

As part of the Safety of Non‐Steroidal Anti‐Inflammatory Drugs (SOS) Project, we reviewed
the incidence of cardiovascular (CV) and gastrointestinal (GI) events associated with the use …

Background Pain is frequent and distressing in people with dementia, but no randomized
controlled trials have evaluated the effect of analgesic treatment on pain intensity as a key …

Aim To assess degree of cyclooxygenase‐2 (COX‐2) selectivity of a non‐steroidal anti‐
inflammatory drug (NSAID) and risk of myocardial infarction (MI) or cerebrovascular accident …

Nabumetone is a nonsteroidal anti-inflammatory prodrug, which exerts its pharmacological
effects via the metabolite 6-methoxy-2-naphthylacetic acid (6-MNA). Nabumetone itself is …

Introduction Nonsteroidal anti-inflammatory drugs (NSAIDs), one of the most commonly used
medications worldwide, are frequently associated with gastrointestinal adverse events …

In patients at high risk of NSAID‐associated serious upper gastrointestinal complications,
gastroprotection with misoprostol or a proton pump inhibitor should be considered. Only …

This review continues a general presentation of the metabolism of drugs and other
xenobiotics begun in five recent issues of Chemistry & Biodiversity. The present Part is …

Background: S-adenosylmethionine (SAMe) has antiinflammatory and analgesie effects and
has been reported to ameliorate the pain and dysfunction of osteoarthritis (OA). The …

Background Adverse consequences of medical interventions are a source of concern, but
clinical trials may lack power to detect elevated rates of such events, while observational …