Insights into the molecular targets and emerging pharmacotherapeutic interventions for nonalcoholic fatty liver disease

CK Negi, P Babica, L Bajard, J Bienertova-Vasku… - Metabolism, 2022 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease
worldwide. With no Food and Drug Administration approved drugs, current treatment options …

[HTML][HTML] Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?

P Rada, Á González-Rodríguez, C García-Monzón… - Cell death & …, 2020 - nature.com
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
worldwide. NAFLD stages range from simple steatosis (NAFL) to non-alcoholic …

[HTML][HTML] Mitochondrial electron transport chain, ROS generation and uncoupling

RZ Zhao, S Jiang, L Zhang… - … journal of molecular …, 2019 - spandidos-publications.com
The mammalian mitochondrial electron transport chain (ETC) includes complexes I‑IV, as
well as the electron transporters ubiquinone and cytochrome c. There are two electron …

Molecular pathways of nonalcoholic fatty liver disease development and progression

F Bessone, MV Razori, MG Roma - Cellular and molecular life sciences, 2019 - Springer
Nonalcoholic fatty liver disease (NAFLD) is a main hepatic manifestation of metabolic
syndrome. It represents a wide spectrum of histopathological abnormalities ranging from …

[HTML][HTML] Reactive oxygen species induce fatty liver and ischemia-reperfusion injury by promoting inflammation and cell death

S Tang, X Mao, Y Chen, L Yan, L Ye, S Li - Frontiers in immunology, 2022 - frontiersin.org
Liver transplantation is the ultimate method for treating end-stage liver disease. With the
increasing prevalence of obesity, the number of patients with non-alcoholic fatty liver, a …

Therapeutic landscape for NAFLD in 2020

BA Neuschwander-Tetri - Gastroenterology, 2020 - Elsevier
Lifestyle modifications focused on healthy eating and regular exercise are the primary
recommendations for patients with nonalcoholic steatohepatitis (NASH). However, for …

Cerium oxide nanoparticles: advances in biodistribution, toxicity, and preclinical exploration

E Casals, M Zeng, M Parra‐Robert, G Fernández‐Varo… - Small, 2020 - Wiley Online Library
Antioxidant nanoparticles have recently gained tremendous attention for their enormous
potential in biomedicine. However, discrepant reports of either medical benefits or toxicity …

Nonalcoholic fatty liver disease pandemic fuels the upsurge in cardiovascular diseases

J Cai, XJ Zhang, YX Ji, P Zhang, ZG She… - Circulation research, 2020 - Am Heart Assoc
Cardiovascular diseases (CVDs) remain a leading cause of death worldwide. Among the
major risk factors for CVD, obesity and diabetes mellitus have received considerable …

Quercetin improves nonalcoholic fatty liver by ameliorating inflammation, oxidative stress, and lipid metabolism in db/db mice

H Yang, T Yang, C Heng, Y Zhou, Z Jiang… - Phytotherapy …, 2019 - Wiley Online Library
Multiphase pathological processes involve in Type 2 diabetes (T2DM)‐induced
nonalcoholic fatty liver disease (NAFLD). However, the therapies are quite limited. In the …

[HTML][HTML] Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway

XJ Zhao, HW Yu, YZ Yang, WY Wu, TY Chen, KK Jia… - Redox Biology, 2018 - Elsevier
Oxidative stress is a critical factor in nonalcoholic fatty liver disease pathogenesis.
MicroRNA-200a (miR-200a) is reported to target Kelch-like ECH-associated protein 1 …