Insights into the molecular targets and emerging pharmacotherapeutic interventions for nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease
worldwide. With no Food and Drug Administration approved drugs, current treatment options …
worldwide. With no Food and Drug Administration approved drugs, current treatment options …
[HTML][HTML] Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?
P Rada, Á González-Rodríguez, C García-Monzón… - Cell death & …, 2020 - nature.com
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
worldwide. NAFLD stages range from simple steatosis (NAFL) to non-alcoholic …
worldwide. NAFLD stages range from simple steatosis (NAFL) to non-alcoholic …
[HTML][HTML] Mitochondrial electron transport chain, ROS generation and uncoupling
RZ Zhao, S Jiang, L Zhang… - … journal of molecular …, 2019 - spandidos-publications.com
The mammalian mitochondrial electron transport chain (ETC) includes complexes I‑IV, as
well as the electron transporters ubiquinone and cytochrome c. There are two electron …
well as the electron transporters ubiquinone and cytochrome c. There are two electron …
Molecular pathways of nonalcoholic fatty liver disease development and progression
F Bessone, MV Razori, MG Roma - Cellular and molecular life sciences, 2019 - Springer
Nonalcoholic fatty liver disease (NAFLD) is a main hepatic manifestation of metabolic
syndrome. It represents a wide spectrum of histopathological abnormalities ranging from …
syndrome. It represents a wide spectrum of histopathological abnormalities ranging from …
[HTML][HTML] Reactive oxygen species induce fatty liver and ischemia-reperfusion injury by promoting inflammation and cell death
S Tang, X Mao, Y Chen, L Yan, L Ye, S Li - Frontiers in immunology, 2022 - frontiersin.org
Liver transplantation is the ultimate method for treating end-stage liver disease. With the
increasing prevalence of obesity, the number of patients with non-alcoholic fatty liver, a …
increasing prevalence of obesity, the number of patients with non-alcoholic fatty liver, a …
Therapeutic landscape for NAFLD in 2020
BA Neuschwander-Tetri - Gastroenterology, 2020 - Elsevier
Lifestyle modifications focused on healthy eating and regular exercise are the primary
recommendations for patients with nonalcoholic steatohepatitis (NASH). However, for …
recommendations for patients with nonalcoholic steatohepatitis (NASH). However, for …
Cerium oxide nanoparticles: advances in biodistribution, toxicity, and preclinical exploration
E Casals, M Zeng, M Parra‐Robert, G Fernández‐Varo… - Small, 2020 - Wiley Online Library
Antioxidant nanoparticles have recently gained tremendous attention for their enormous
potential in biomedicine. However, discrepant reports of either medical benefits or toxicity …
potential in biomedicine. However, discrepant reports of either medical benefits or toxicity …
Nonalcoholic fatty liver disease pandemic fuels the upsurge in cardiovascular diseases
Cardiovascular diseases (CVDs) remain a leading cause of death worldwide. Among the
major risk factors for CVD, obesity and diabetes mellitus have received considerable …
major risk factors for CVD, obesity and diabetes mellitus have received considerable …
Quercetin improves nonalcoholic fatty liver by ameliorating inflammation, oxidative stress, and lipid metabolism in db/db mice
H Yang, T Yang, C Heng, Y Zhou, Z Jiang… - Phytotherapy …, 2019 - Wiley Online Library
Multiphase pathological processes involve in Type 2 diabetes (T2DM)‐induced
nonalcoholic fatty liver disease (NAFLD). However, the therapies are quite limited. In the …
nonalcoholic fatty liver disease (NAFLD). However, the therapies are quite limited. In the …
[HTML][HTML] Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway
XJ Zhao, HW Yu, YZ Yang, WY Wu, TY Chen, KK Jia… - Redox Biology, 2018 - Elsevier
Oxidative stress is a critical factor in nonalcoholic fatty liver disease pathogenesis.
MicroRNA-200a (miR-200a) is reported to target Kelch-like ECH-associated protein 1 …
MicroRNA-200a (miR-200a) is reported to target Kelch-like ECH-associated protein 1 …