Approximately 100,000 primary and metastatic brain tumor patients/year in the US survive
long enough (> 6 months) to experience radiation-induced brain injury. Prior to 1970, the …

Cerebral small vessel disease (SVD) gives rise to one in five strokes worldwide and
constitutes a major source of cognitive decline in the elderly. SVD is known to occur in …

Here, we highlight the potential translational benefits of delivering FLASH radiotherapy
using ultra-high dose rates (> 100 Gy⋅ s− 1). Compared with conventional dose-rate …

Abstract Each year, approximately 200,000 patients in the United States will receive partial-
or whole-brain irradiation for the treatment of primary or metastatic brain cancer. Early and …

Age-related impairment of angiogenesis likely has a critical role in cerebromicrovascular
rarefaction and development of vascular cognitive impairment and dementia (VCID) in the …

Radiation therapy is the most effective non-surgical treatment of primary brain tumors and
metastases. Preclinical studies have provided valuable insights into pathogenesis of …

BACKGROUND As cancer survival rates improve, understanding and preventing the
adverse off-target and long-term impacts of cancer treatments, including impacts on fertility …

Epidemiological studies show that obesity has deleterious effects on the brain and cognitive
function in the elderly population. However, the specific mechanisms through which aging …

Whole brain irradiation (WBI, also known as whole brain radiation therapy or WBRT) is a
mainstream therapy for patients with identifiable brain metastases and as a prophylaxis for …

Whole brain irradiation (WBI), a commonly employed therapy for multiple brain metastases
and as a prophylactic measure after cerebral metastasis resection, is associated with a …