The review of the 2016–2017 marine pharmacology literature was prepared in a manner
similar as the 10 prior reviews of this series. Preclinical marine pharmacology research …

Covering: up to 2019 Nature furnishes bioactive compounds (natural products) with complex
chemical structures, yet with simple, sophisticated molecular mechanisms. When natural …

The increase in speed of the high-speed atomic force microscopy (HS-AFM) compared to
that of the conventional AFM made possible the first-ever visualisation at the molecular-level …

Amphidinol 3 (AM3) is a potent antifungal produced by the dinoflagellate Amphidinium
klebsii. It was difficult to determine the absolute configuration of AM3 by using the scarce …

Dinoflagellates are an ecologically important group of marine microbial eukaryotes with a
remarkable array of adaptive strategies. It is ironic that two of the traits for which …

Dinoflagellate-derived polyketides are typically large molecules (> 1000 Da) with complex
structures, potent bioactivities, and high toxicities. Their discovery suffers three major …

The exploration of molecular recognition in lipid bilayers is still extremely difficult. In this
report, we leveraged short-range energy transfer (ET) that enabled detection of close …

Molecular mechanisms underlying channel-membrane interplay have been extensively
studied. Cholesterol, as a major component of the cell membrane, participates either in …

Abstract In 1957 Abbott and Ballantine described a highly toxic activity from a dinoflagellate
isolated from the English Channel in 1949 by Mary Park. From a culture maintained at …

The demand for valuable products from dinoflagellate biotechnology has increased
remarkably in recent years due to their many prospective applications. However, there …