Regulatory T cells (Treg cells) are a small subset of immune cells that are dedicated to
curbing excessive immune activation and maintaining immune homeostasis. Accordingly …

Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

Coordinated function of the innate and adaptive arms of the immune system in vertebrates is
essential to promote protective immunity and to avoid immunopathology. The Notch …

Type 1 diabetes mellitus (T1D) is a chronic, multifactorial autoimmune disease that involves
the progressive destruction of pancreatic β-cells, ultimately resulting in the loss of insulin …

CD8+ Tregs have been long described and significant progresses have been made about
their phenotype, their functional mechanisms, and their suppressive ability compared to …

Regulatory T cell (Treg) therapy has shown promise in early clinical trials for treating graft-
versus-host disease, transplant rejection and autoimmune disorders. A challenge has been …

Recently, increased interest in the use of Tregs as adoptive cell therapy for the treatment of
autoimmune diseases and transplant rejection had led to several advances in the field …

Autoimmunity is caused by an unbalanced immune system, giving rise to a variety of organ-
specific to system disorders. Patients with autoimmune diseases are commonly treated with …

Regulatory T cells (Tregs) have enormous therapeutic potential to treat a variety of
immunopathologies characterized by aberrant immune activation. Adoptive transfer of ex …

Abstract Purpose of Review Low-grade inflammation drives elevations in blood pressure
(BP) and consequent target organ damage in diverse experimental models of hypertension …