Cancer epigenetics: Moving forward
A Nebbioso, FP Tambaro, C Dell'Aversana… - PLoS genetics, 2018 - journals.plos.org
Defects in chromatin modifiers and remodelers have been described both for hematological
and solid malignancies, corroborating and strengthening the role of epigenetic aberrations …
and solid malignancies, corroborating and strengthening the role of epigenetic aberrations …
Dangerous liaisons: interplay between SWI/SNF, NuRD, and Polycomb in chromatin regulation and cancer
Abstract Changes in chromatin structure mediated by ATP-dependent nucleosome
remodelers and histone modifying enzymes are integral to the process of gene regulation …
remodelers and histone modifying enzymes are integral to the process of gene regulation …
[HTML][HTML] Updated diagnostic criteria and nomenclature for neurofibromatosis type 2 and schwannomatosis: An international consensus recommendation
Abstract Purpose Neurofibromatosis type 2 (NF2) and schwannomatosis (SWN) are
genetically distinct tumor predisposition syndromes with overlapping phenotypes. We …
genetically distinct tumor predisposition syndromes with overlapping phenotypes. We …
Atypical teratoid/rhabdoid tumors are comprised of three epigenetic subgroups with distinct enhancer landscapes
Atypical teratoid/rhabdoid tumor (ATRT) is one of the most common brain tumors in infants.
Although the prognosis of ATRT patients is poor, some patients respond favorably to current …
Although the prognosis of ATRT patients is poor, some patients respond favorably to current …
Cancer surveillance in Gorlin syndrome and rhabdoid tumor predisposition syndrome
Gorlin syndrome and rhabdoid tumor predisposition syndrome (RTPS) are autosomal
dominant syndromes associated with an increased risk of childhood-onset brain tumors …
dominant syndromes associated with an increased risk of childhood-onset brain tumors …
SMARCB1-deficient cancers: novel molecular insights and therapeutic vulnerabilities
Simple Summary Loss of SMARCB1 has been identified as the sole mutation in a number of
rare pediatric and adult cancers, most of which have a poor prognosis despite intensive …
rare pediatric and adult cancers, most of which have a poor prognosis despite intensive …
The molecular pathogenesis of schwannomatosis, a paradigm for the co-involvement of multiple tumour suppressor genes in tumorigenesis
H Kehrer-Sawatzki, S Farschtschi, VF Mautner… - Human genetics, 2017 - Springer
Schwannomatosis is characterized by the predisposition to develop multiple schwannomas
and, less commonly, meningiomas. Despite the clinical overlap with neurofibromatosis type …
and, less commonly, meningiomas. Despite the clinical overlap with neurofibromatosis type …
Relevance of molecular groups in children with newly diagnosed atypical teratoid rhabdoid tumor: results from prospective St. Jude multi-institutional trials
SA Upadhyaya, GW Robinson, A Onar-Thomas… - Clinical cancer …, 2021 - AACR
Purpose: Report relevance of molecular groups to clinicopathologic features, germline
SMARCB1/SMARCA4 alterations (GLA), and survival of children with atypical teratoid …
SMARCB1/SMARCA4 alterations (GLA), and survival of children with atypical teratoid …
SMARCB1-deficient Tumors of Childhood: A Practical Guide
BR Pawel - Pediatric and Developmental Pathology, 2018 - journals.sagepub.com
The SMARCB1 gene (INI1, BAF47) is a member of the SWItch/Sucrose Non-Fermentable
(SWI/SNF) chromatin remodeling complex, involved in the epigenetic regulation of gene …
(SWI/SNF) chromatin remodeling complex, involved in the epigenetic regulation of gene …
Atypical teratoid/rhabdoid tumors: challenges and search for solutions
A Biswas, L Kashyap, A Kakkar, C Sarkar… - Cancer management …, 2016 - Taylor & Francis
Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant embryonal central nervous
system tumor commonly affecting children< 3 years of age. It roughly constitutes 1%–2% of …
system tumor commonly affecting children< 3 years of age. It roughly constitutes 1%–2% of …