Signaling by the Wnt family of secreted glycoproteins plays important roles in embryonic
development and adult homeostasis. Wnt signaling is modulated by a number of …

Teeth are found in almost all vertebrates, and they therefore provide a general paradigm for
the study of epithelial organ development and evolution. Here, we review the developmental …

Muscle-specific tyrosine kinase myasthenia gravis (MuSK MG) is an autoimmune disease
that causes life-threatening muscle weakness due to anti-MuSK autoantibodies that disrupt …

For more than a decade, Wnt signaling pathways have been the focus of intense research
activity in bone biology laboratories because of their importance in skeletal development …

Dental anomalies are caused by complex interactions between genetic, epigenetic and
environmental factors during the long process of dental development. This process is …

Wnt signaling executes an indispensable performance in osteoblast differentiation, bone
development, homeostasis, and remodeling. Wnt signals trigger the intracellular Wnt …

Humans lacking sclerostin display progressive bone overgrowth due to increased bone
formation. Although it is well established that sclerostin is an osteocyte-secreted bone …

The Wnt/β-catenin signaling pathway is one of several key conserved intercellular signaling
pathways in animals, and plays fundamental roles in the proliferation, regeneration …

Teeth play essential roles in life. Their development relies on reciprocal interactions
between the ectoderm-derived dental epithelium and the underlying neural crest-originated …

Organogenesis depends upon a well-ordered series of inductive events involving
coordination of molecular pathways that regulate the generation and patterning of specific …