Due to the advantages in efficacy and safety compared with traditional chemotherapy drugs,
targeted therapeutic drugs have become mainstream cancer treatments. Since the first …

Platelet-derived growth factors (PDGF) promotes cell proliferation, survival and migration,
primarily of cells of mesenchymal origin. Dysfunction of PDGF signaling has been observed …

In cancer, the primary tumour's organ of origin and histopathology are the strongest
determinants of its clinical behaviour, but in 3% of cases a patient presents with a metastatic …

Cell proliferation requires nutrients, energy, and biosynthetic activity to duplicate all
macromolecular components during each passage through the cell cycle. It is therefore not …

The extent to which the three-dimensional organization of the genome contributes to
chromosomal translocations is an important question in cancer genomics. We generated a …

Natural products have inspired chemists and physicians for millennia. Their rich structural
diversity and complexity has prompted synthetic chemists to produce them in the laboratory …

The BCR-ABL1 fusion gene is a driver oncogene in chronic myeloid leukaemia and 30–50%
of cases of adult acute lymphoblastic leukaemia. Introduction of ABL1 kinase inhibitors (for …

Genome instability is a prerequisite for the development of cancer. It occurs when genome
maintenance systems fail to safeguard the genome's integrity, whether as a consequence of …

Tuberculosis continues to kill 1· 4 million people annually. During the past 5 years, an
alarming increase in the number of patients with multidrug-resistant tuberculosis and …

Chronic myelogenous leukemia (CML) is an indolent malignant hematological disease that
accounts for about 15% of all cases of leukemia. This disorder results from the formation of …