The case for cloud computing in genome informatics | Genome Biology Skip to main content
SpringerLink Account Menu Find a journal Publish with us Track your research Search Cart …

Genomic tiling arrays, cDNA sequencing and, more recently, RNA-Seq have provided initial
insights into the extent and depth of transcribed sequence across human and other …

Enhancers control the correct temporal and cell-type-specific activation of gene expression
in multicellular eukaryotes. Knowing their properties, regulatory activity and targets is crucial …

Methylation of the N 6 position of adenosine (m 6 A) is a posttranscriptional modification of
RNA with poorly understood prevalence and physiological relevance. The recent discovery …

Only a very small fraction of long noncoding RNAs (lncRNAs) are well characterized. The
evolutionary history of lncRNAs can provide insights into their functionality, but the absence …

Housekeeping (HK) genes are constitutively expressed genes that are required for the
maintenance of basic cellular functions. Despite their importance in the calibration of gene …

FMRP loss of function causes Fragile X syndrome (FXS) and autistic features. FMRP is a
polyribosome-associated neuronal RNA-binding protein, suggesting that it plays a key role …

We have developed a new generation of genome-wide DNA methylation BeadChip which
allows high-throughput methylation profiling of the human genome. The new high density …

High-throughput sequencing platforms are generating massive amounts of genetic variation
data for diverse genomes, but it remains a challenge to pinpoint a small subset of …

Abstract The UCSC Genome Browser (http://genome. ucsc. edu) is a graphical viewer for
genomic data now in its 13th year. Since the early days of the Human Genome Project, it has …