• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

LRRC4 is a novel relatively specific gene, which displays significant down-regulation in
primary brain tumor biopsies and has the potential to suppress brain tumor growth. In this …

Abstract Aims The EURO-ENDO registry aimed to study the management and outcomes of
patients with infective endocarditis (IE). Methods and results Prospective cohort of 3116 …

Infective endocarditis is defined by a focus of infection within the heart and is a feared
disease across the field of cardiology. It is frequently acquired in the health care setting, and …

The arrival of cell-based therapies is a revolution in medicine. However, its safe clinical
application in a rational manner depends on reliable, clinically applicable methods for …

Immunotherapy, specifically the introduction of immune checkpoint inhibitors, has
transformed the treatment of cancer, enabling long-term tumour control even in individuals …

Purpose Single-photon emission computed tomography (SPECT) combined with computed
tomography (CT) was introduced as a hybrid SPECT/CT imaging modality two decades ago …

Background—The diagnosis of infective endocarditis (IE) in prosthetic valves and
intracardiac devices is challenging because both the modified Duke criteria (DC) and …

Objectives: This study sought to determine the value of 18F-fluorodeoxyglucose positron
emission tomography/computed tomography (18F-FDG PET/CT) for diagnosing prosthetic …

Sensitivity and specificity of the modified Duke criteria for native valve endocarditis are both
suboptimal, at approximately 80%. Diagnostic accuracy for intracardiac prosthetic material …