Psychiatric genetics and the structure of psychopathology
For over a century, psychiatric disorders have been defined by expert opinion and clinical
observation. The modern DSM has relied on a consensus of experts to define categorical …
observation. The modern DSM has relied on a consensus of experts to define categorical …
Autism genetics: opportunities and challenges for clinical translation
Genetic studies have revealed the involvement of hundreds of gene variants in autism. Their
risk effects are highly variable, and they are frequently related to other conditions besides …
risk effects are highly variable, and they are frequently related to other conditions besides …
Identification of common genetic risk variants for autism spectrum disorder
Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic …
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic …
Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups
Attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are
highly heritable neurodevelopmental conditions, with considerable overlap in their genetic …
highly heritable neurodevelopmental conditions, with considerable overlap in their genetic …
Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
MJ Gandal, JR Haney, NN Parikshak, V Leppa… - Science, 2018 - science.org
The predisposition to neuropsychiatric disease involves a complex, polygenic, and
pleiotropic genetic architecture. However, little is known about how genetic variants impart …
pleiotropic genetic architecture. However, little is known about how genetic variants impart …
A phenotypic spectrum of autism is attributable to the combined effects of rare variants, polygenic risk and sex
The genetic etiology of autism spectrum disorder (ASD) is multifactorial, but how
combinations of genetic factors determine risk is unclear. In a large family sample, we show …
combinations of genetic factors determine risk is unclear. In a large family sample, we show …
Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders
Autism spectrum disorder (ASD) risk is influenced by common polygenic and de novo
variation. We aimed to clarify the influence of polygenic risk for ASD and to identify …
variation. We aimed to clarify the influence of polygenic risk for ASD and to identify …
Distinguishing genetic correlation from causation across 52 diseases and complex traits
LJ O'Connor, AL Price - Nature genetics, 2018 - nature.com
Mendelian randomization, a method to infer causal relationships, is confounded by genetic
correlations reflecting shared etiology. We developed a model in which a latent causal …
correlations reflecting shared etiology. We developed a model in which a latent causal …
Autism spectrum disorder: Consensus guidelines on assessment, treatment and research from the British Association for Psychopharmacology
An expert review of the aetiology, assessment, and treatment of autism spectrum disorder,
and recommendations for diagnosis, management and service provision was coordinated …
and recommendations for diagnosis, management and service provision was coordinated …
Predicting polygenic risk of psychiatric disorders
Genetics provides two major opportunities for understanding human disease—as a
transformative line of etiological inquiry and as a biomarker for heritable diseases. In …
transformative line of etiological inquiry and as a biomarker for heritable diseases. In …